Medscape Update on the Management of Atopic Dermatitis What Clinicians Need to Know Michael J. Cork, BSc, MB, PhD, FRCP Consultant Dermatologist, Sheffield Children's Hospital and Teaching Hospitals Head of Sheffield Dermatology Research (SDR) Department of Infection, Immunity and Cardiovascular Disease University of Sheffield Medical School Sheffield, United KingdomBackground * AD is a chronic, relapsing inflammatory skin diseasel*l * AD places a significant burden on patients by negatively affecting:!! — Quality of life — Work — Family * Burden is felt by patients with mild to moderate and moderate to severe AD!) a. Zuberbier T, et al. J Allergy Clin Immunol. 2006;118:226-232. b. Hebert AA, et al. Curr Med Res Opin. 2018;34:2177-2185.Burden of AD: Severe Disease “It was too painful to move or be exposed to the air. My ankles, feet and legs swelled up and | could not stand or use my hands” Images courtesy of Michael J. Cork, BSc, MB, PhD, FRCP.