‘The NEW ENGLAND JOURNAL of MEDICINE ORIGINAL ARTICLE Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes The Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators* This article was published at www.nejm.org on March 14, 2006. N Engl J Med 2006;354:1464-76. Copyright © 2006 Massachusetts Medical Society.‘A. Death, Myocardial Infarction, or Refractory Ischemia through Day 9 Hazard ratio, 1.01 (95961, 0.90-2.13) Fondaparinux Enoxaparin Cumustiva Hazard No. at Risk Enonaparin 10,021 9954 9824 9724 9652 9592 9550 9515 9470 10.057 0086 GHs6 9752 Gee GEE OSE0 Bs41 OSI0 Fondapaimu B Majer Bleeding through Day 9 BOT Hazard ratio, 0.52 (95% Cl, 0.44-0.61) Enoxaparin Fondaparinus Ccumubtve Hazard No. at Risk 10,021 6,979 9871 9774 96a? 9625 9575 G527 Gare Enowaparin Fondlapainun 10,057 10,028 9951 9884 9838 9796 S7Ts 973K 9709 Figure 1. Cumulative Risks of Death, Myocardial Infarction, or Refractory lechemia (Panel A) and of Major Bleeding (Panel B) through Day 9. The hazard ratios are for the fondaparinux group as compared with the enoxaparin group. Cl denotes confidence interval.‘A Death through Day 180 Haz ard ratio, 0.89 (9594 Cl, 0.80- 1.00) onc] peo'us z roe § Enoxaparin = cos. Ps 3 EZ 002 000. 3 30 #0 ako «ao —«bo Days No. at Risk Enocaperin, 10,021«9673.««9574 0495504506 8322 Fondaporimac 10.057 5762 S864. S385 BELL BSay «ESE B Death, Myocardial Infarction, or Stroke through Day 180 Hac ard ratio, 0.89 (9596 Cl, 0.82~0.97) poo ‘oar Tondapadinee z Enoxepacin, | 3 E 3 % & 3 ato ~«iS0—«ado Days No. at Risk 1ooz. 92749105985 g07e 79717772 Enonaparin 1003793909258 = S110 BIL 033 PRS Fondaparinen: igure 2. Curnulative Risks of Death (Panel A) and of Death, Myocardial Infarction, or Stroke (Panel B) through Day 180. The hazard ratios are for the fondaparinux group as compared with the enoxaparin group. Cl denotes confidence interval