HEMATOPOESIS

Eritropoesis

Eritrosit
Sel Induk
Multi Potensial Granulopoesis Granulosit

Sel Induk Monosit

Pluri Potensial Megakaryositopoesi

Trombosit

Limposit T

Sel Induk Limpopoesis

Limfoid Limposit B

1
 HEMATOPOESIS PADA EMBRIO

YOLK SAC 
 
 

SST

 
LIVER
HEPATIK MYELOID
 
 SPLEEN
MESOBLASTIK   LYMPHNODE

1 2 3 4 5 6 7 8 9 10
ASAL USUL DARAH

Monophyletic Teori Reticulo Endothelium Undiff Mesenchym

( Maxiwon ) Hemo Histioblast
Myeloblast ( Hemocytoblast )

Polyphyletic Teori Mesoderm ( Embrio ) – Toti Potensial

( Naegelietal ) Mesenchym & Endothelium – Multi Potensial
1. Extra Vasculer Origin  Mesenchym Multipotent - Myelobalst
- Monobalst
-Lympobalst
2.Intra Vaskuler Origin  Endothel Duo Potent - Erythroblast
- Histiocyte
3.Intra & Extra
PARAMETER DASAR
HEMATOLOGI

1.Hb ( Lk 14 – 16 gr % ) 3. Ht
( Pr 12 – 14 gr % ) 4.Lekosit
2.Eritrosi 5.Trombosit
Ht
MCV = x 10 = 85  10 fl
Eri
Hb
MCH = x 10 = 29,5  2,5 pg
Eri
Hb
MCHC = x 100 % = 32,5  2,5 %
Ht
 Anemia ( Morfologis )

Macrositer Hyperchrom
Normositer Normocrom
Micrositer Hypochrom

Defisiensi : Fe, Folat , Vit B 12

Hemolitik
Anemia
( klinis ) Hemorrhagik
Aplastik
PEMERIKSAN BAHAN KHUSUS

ANEMIA DEFF Fe

Serum Iron
TIBC
Saturation Transferin
Ferritin
Serum Transferin
Hemosiderin Urine, SST
ANEMIA HEMOLITIK
Hb Plasma Elektroforese
Hb F
Sugar water Test
Ham’s Test
Resistensi Osmotik
Coomb’s Test Direct & Indirect
Spesifik Antibodi
Ig G, M, A, D.
Serum Protein
Monoklonal Antibodi
Vit B12 Serum , Folat Serum
Eritrosit Life Span
Reticulocyte Count
G6PD & Enzim Eritrosit
BMP & Biopsi
HEMATOPOETIK STEM SEL
 ANEMIA NORMOKROM NORMOSITER

Anemia Normokrom Normositer

 Retikulosit ( N ) / Menurun

Ax, Fx, Hapusan Darah Bilirubin BMA / Biopsi

Anemia Hemolitik Perdarahan Akut

BM : (Abn ) BM : ( N )

Aplastik Infiltrasi DMPS TF Ginjal TF Hati TF Endkr Serum

Leukemia, mieloma CRF Anemia Myxedema Anemia

Mielofibrosis, metastase peny hati Addison Peny kronik
 ANEMIA HIPOKROM MIKROSITER

Anemia Hipokrom Mikrositer

Serum Fe

Menurun (N) Meningkat

Fe Sutul Ferritin

Elektroforese Hb dsb Fe Sutul meningkat

( Sideroblast )
( - )  Def Besi  Rendah
Anemia Sideroblastik
 Anemia  ( N ) / ( ? ) Thalasemia
Penyakit Kronik Hb – pati Kongenital
di dapat
ANEMIA YANG SERING DI JUMPAI DI
INDONESIA
ANEMIA DEFISIENSI BESI
ANEMIA INFLAMASI
ANEMIA MEGALOBLASTIK ( DEF ASAM FOLAT )
ANEMIA HEMOLITIK
 - THALASEMIA
OBAT – OBATAN
ANEMIA ec INSUFISIENSI RENAL
ANEMIA GRAVIDARUM