Captopril (ACE-i) Pharmacokinetic

Dosage forms of this class of ACE inhibitors such as

tablet, film coated tablet, caplet, film coated caplet.
ACE inhibitor drugs will be absorbed through the
gastrointestinal tract. These drugs should be given
half an hour before meals or two hours after a meal
because the absorption of captopril is reduced by 30-
40% in the presence of food in the stomach, and the
drug is eliminated via the renal so the drug dose
should be reduced for people who have kidney
insuffisiensi. Most ACE inhibitors can be given 1 time
/ day except captopril, a short half-life time, usually
two to three times / day
Captopril (ACE-i)
Pharmacodynamic
ACE is widely distributed in many tissues, generally in cell
endotelal. Because vascular endothelial covering a large
area, the main place of production of angiotensin II is a
blood vessel, instead of the kidney. ACE inhibitors block
the changes of angiotensin I to angiotensin II, a potent
vasoconstrictor that stimulates the secretion of
aldosterone. ACE inhibitors also block the degradation of
bradykinin and stimulates the synthesis of compounds
other vasodilators, such as prostaglandin E2 and
prostacyclin. The fact that ACE inhibitors reduce blood
pressure in patients with normal plasma renin and ACE
activity may indicate the importance of bradykinin and
ACE production in the network as a cause of increased
peripheral vascular arrest.
ACE inhibitors also block the degradation of
bradykinin and stimulates the synthesis of
substances that cause vasodilation, including
prostaglandin E2 and prostacyclin. Increased
bradykinin increases the blood pressure lowering
effect of ACE inhibitors, but also responsible for the
side effects of a dry cough which is often
encountered in the use of ACE inhibitors. ACE
inhibitors are effective in preventing and left
ventricular hypertrophy regressed by reducing direct
stimulation by angiotensin II on myocardial cells.