 Cushing syndromeis caused by prolonged

exposure to eleveted levels of either

endogenous glucocorticoids or exogenous
glucocorticoids.

CUSHING SYNDROME
 Caused
o Hiperplasia adrenal
o Hiperplasia noduller adrenal
o Neoplasia adrenal
o Iatrogenik
 Sign and symptoms
oMoon facies
oBuffalo hump
oPurple striae
oHirsutism
oMenstrual irregularities / amenorrhea
oImpotence
oOsteopenia, osteoporotic fractures
 Workup
oCortisol plasma
oDexamethasone suppression
oUrinary free cortisol
 Medication
oMetyrapone, inhibitor of endogenous adrenal
corticosteroid synthesis
oKetoconazole
oAminoglutethimide
oMifespristone