Glucose has FOUR primary metabolic fates:

Glucose has FOUR primary metabolic fates:

-Conversion to pyruvate (glycolysis)

Glucose has FOUR primary metabolic fates:

-Conversion to pyruvate (glycolysis)

-Storage (glycogen)
Glucose has FOUR primary metabolic fates:

-Conversion to pyruvate (glycolysis)

-Storage (glycogen)

-PPP to make Ribose-5-phosphate & NADPH

Glucose has FOUR primary metabolic fates:

-Conversion to pyruvate (glycolysis)

-Storage (glycogen)

-PPP to make Ribose-5-phosphate & NADPH

-Formation of polysaccharides (ExtraCellular Matrix, etc)

Understanding what’s
normal to identify
what’s not…

*GLUT1 & 2
(hepatocytes) vs.
GLUT4 (muscle)
regulation
HW Ch 14 #9: 14C-labeled G3P is added to a yeast extract. After awhile,
fructose 1,6-bisphosphate labeled with 14C at C-3 and C-4 is isolated.
Where was G3P labelled? Why does the product have two 14Cs?
HW Ch 14 #9: 14C-labeled G3P is added to a yeast extract. After awhile,
fructose 1,6-bisphosphate labeled with 14C at C-3 and C-4 is isolated.
Where was G3P labelled? Why does the product have two 14Cs?
Oxidative Phase of PPP
Pentose Phosphate Pathway
 Non-Oxidative Phase of PPP

* *

The non-oxidative reactions recycle R5P back to glucose so the oxidative

reactions can continue.
*Specific to PPP
Which enzymes are in glycolysis/gluconeogenesis?
-Dividing cells need
R5P (bone marrow, skin)

-Cells making FA (liver,

Adipose, etc) need NADPH
as well as cells exposed to
air (for oxidative protection)
like erythrocytes/lens/
cornea

-The oxidative phase

produces R5P and NADPH
 OH

O C O O O
H2 H2 H H
CH C C C N CH C N CH C OH

NH2 CH2 H

SH

GSH: glutathione
-Glu-Cys-Gly
HW Ch. 14 #28: Phloridzin, a toxic glycoside from the bark of the pear tree,
blocks the normal reabsorption of Glc from the kidney tubule, causing blood
Glc to be excreted in the urine. Rats fed phloridzin and sodium succinate
excreted 0.5 mol of Glc for every mol of succinate ingested. How is the
succinate transformed to Glc?