TOXIC WAISTLINES IMPAIR

LONGEVITY

Stephen Holt, MD, PhD, DSc, DNM, LLD.

Distinguished Professor of Medicine
(Emeritus)
Scientific Advisor, Natural Clinician LLC
Contact: drholt@hiom.org
 WEIGHT CONTROL
(COMPREHENSIVE PROGRAM)
• Calorie Control
• Energy Expenditure
• Socio-behavioral Interventions
• Detoxification
• Sleep Restoration
• Stress Management
• Insulin Resistance/Syndrome X
 THE POT BELLY
•The hallmark of obesity in mature subjects and
waistline expansion is common in Syndrome X.
•A sign of visceral adiposity associated with “ugly
disease companions of obesity”.
•Visceral fat elaborates hormones and inflammatory
messenger molecules
•Visceral fat concentrates organic chemicals that can
interfere with intermediary metabolism in fat stores
e.g. organophosphates, parabens etc.
•The pot belly is a “toxic waste dump” in the body
and it is a “useless acquired endocrine organ”.
 DETOXIFICATION
•Organochemicals appear to important
miscreants in obesity
•Lessons from the 9/11 World Trade Center
collapse where rescue workers developed
Metabolic Syndrome X as a result of several
factors, including toxicants.
•Standard detoxification protocols do not
effectively eliminate organic toxins that are
stored in in visceral fat.
 DETOXIFICATION
•Extensive detoxification programs involving sauna
(about 33 continuous days), vitamin supplement
regimens, exercise and lifestyle change are quite
effective (9/11 Detox Program, Manhattan).
•Ancillary detoxification techniques may add value
but are unlikely to succeed when used alone e.g.
colon cleansing, colon hydrotherapy, dietary
changes, chelation therapies etc.
•There is a clear evidence-base to approach obesity
management from a perspective of environmental
medicine and detoxification programs are emerging
as evidence-based in weight loss protocols.
 THERMOGENESIS
• Heat production by the body
• Obligatory (digestion, absorption
and metabolism)
• Adaptive (increase in metabolic
rate stimulated by eating)
 THERMOGENIC
NUTRACEUTICALS
• Caffeine*
• Green Tea Polyphenols
• Coffee Bean Polyphenols
• Fucoxanthin
• Hydroxycitrate*
• Berry Antioxidants*
• Natural Amines (p-synephrine)
• *PROBLEMS
 NATURAL “AMINES”
(PLANT ALKALOIDS)
• Stimulate adrenergic receptors:
alpha-1, alpha-2, Beta-1, Beta-2,
Beta-3, ephedra is non-selective
• Beta-3 receptor semi-selectivity
(p-synephrine)
• Patented extracts of Citrus
aurantium (ADVANTRA Z)
CITRUS AURANTIUM EXTRACTS:
ADVANTRA Z (P-SYNEPHRINE)
• P-Synephrine has less propensity to
stimulate cardiovascular or CNS function
(BP, Heart Rate/Arrythmogenesis), but
may increase muscle mass (increased
muscle uptake of amino acids).
• Evidence-base for: lipolysis,
thermogenesis, ergogenesis, increased
muscle mass.
 ADVANTRA Z PATENTS
• U.S. 6,224,873: Regulation of appetite, body weight
and athletic function with materials derived from citrus
varieties.

• U.S. 6,316,499: Methods for increasing muscle mass

of a human with materials derived from citrus varieties.

• U.S. 6,340,481: Regulation of athletic function with

materials derived from citrus varieties.

• U.S. 6,340,482: Methods for inducing weight loss in a

human with materials derived from Citrus varieties.
 SAFETY DATA (ADVANTRA
Z)
• Ephedra withdrawal 2004, New
York Times Article, 2004.
• Case reports, but combinations and
incomplete reporting cloud the
issues (Nykamp et al, 2004)
• No serious adverse event reporting
or product liability claims (>10y.)
SAFETY DATA (ADVANTRA Z)
• Haller et al, 2000, blood pressure rose
post exercise but normalized at 90 min
(peak diastolic BP)
• Talbott et al, 2007, Advantra Z (80mg of
p-synephrine) showed no increase in BP,
resting heart rate over six weeks of
supplementation.
• Haaz et al, 2006, generally stable heart
rate and BP in humans, animals variable.
 ADVANTRA Z EFFICACY
• Gougeon et al, 2008. Advantra Z increases
metabolic rate and enhances thermal
responses to food, notably in females.
• Preuss et al, 2002. “Citrus aurantium may be
the best thermogenic susbstitute for ephedra”.
• Metabolic rate increase with Advantra Z and
p-synephrine in several clinical observations
(Germano C. “Advantra Z”, Kensington
Publishers, 1998, Holt S, “Peel Off the
Weight”, HIOM, 2009).
 ADVANTRA Z EFFICACY
(SUMMARY)

• Three studies show weight loss: Colker

et al, 1999, Jones, 2001, Germano, 1998
• Four studies show enhancement of
metabolic rate: Colker et al, 1999,
Pathak and Gougeon, 1999, Hedrei and
Gougeon, 1997, Germano, 1998)
CAUTIONS WITH AMINES

• Children, Pregnancy
• MAO Inhibitors/Cough Cold
Remedies
• Established cardiovascular or
stroke risk
 METABOLIC SYNDROME X

• A key management initiative to

promote longevity. It highlights
the most significant components
of the pathophysiology of obesity.
• Clinical Metabolic Syndrome X
Nutritional Factors
 MARINE FISH OIL
• EPA and DHA in at least a dosage of
600 mg and 400 mg, respectively.
• Enhanced bioavailability of active fatty
acids and improved patient compliance
by enteric coating.
• Cardiovascular and anti-inflammatory
benefits with PPAR-receptor actions.
Very important in Syndrome X.
COMBAT SLEEPLESSNESS
• Sleep deprivation alters hormonal
controls of appetite, ghrelin increase,
leptin decrease.
• Restoration of sleep rhythms may cause
weight loss without other interventions.
• Sleeplessness induces stress response.
• Insulin resistance decreased with sleep.
CALORIE RESTRICTION
MIMETICS
• CR increases average and maximum
lifespan
• CRM can “mimic” the beneficial
biophysiological changes that occur
during CR
• “Clinical Calorie Restriction Mimetics”
(cinnamon, avocado, resveratrol,
gymnema, alpha lipoic acid)
 ANTI-AGING SIGNIFICANCE

• Excess bodyweight is associated with

premature morbidity and mortality.
• 70 million Americans have Syndrome X.
• Calorie restriction mimetics often
regulate blood glucose and decrease
insulin resistance.
• Telomere shortening is associated with
insulin resistance and CVS disease.
 FACT
• OBESE KIDS BECOME UNHAPPY,
UNHEALTHY OBESE ADULTS
 CONCLUSION
• Patented extracts of Citrus aurantium
(Advantra Z) are the most credible
evidence-based weight loss
nutraceuticals to date.
• Thermogenesis combined with lipolysis,
ergogenesis and retain lean body mass
occur with ADVANTRA Z.
• Calorie Restriction is a cornerstone for
weight control and longevity promotion
(Calorie Restriction Mimetics)

Contact: drholt@hiom.org