difficulty concentrating at work has been more irritable with her coworkers persistent rash over her shins that has not improved with the use of topical steroid creams weight loss of about 10 lb ,insomnia, and amenorrhea for the past 2 months on examination, she is afebrile. her pulse varies from 70 to 110 beats/min she appears restless and anxious her skin is warm and moist her eyes show evidence of exophthalmos and lid retraction bilaterally neck examination reveals symmetric thyroid enlargement, without any discrete palpablemasses cardiac examination reveals an irregular rhythm She has problem resting hand tremor , difficulty concentrating at work and has been more irritable with her coworkers The hipotesa is hyperthyroidism DEFINISION Etiology Symptoms Risk factors Physical examination and investigation Treatment and education COMPLICATION Hyperthyroidism is a condition caused by a clinic excessive secretion of thyroid hormones are thyroxine (T4) and triiodothyronine (T3). Also found an increase in the production of triiodothyronine (T3) as a result of increasing the conversion of thyroxine (T4) in the peripheral tissues. . The disease is a form of hyperthyroidism tiroktoksikosis most often encountered in daily practice . Can occur at any age , often found in women than men . Hyperthyroid disease pathogenesis has so far not known The mechanism of autoimmunity is an important factor in the pathogenesis of hyperthyroidism Patients complain of fatigue , trembling , can not stand the heat , sweat more when hot , moist skin , weight loss despite increased appetite , palpitations , tachycardia , diarrhea and weakness and muscle atrophy . •Occurs more in women than in men •At the age of 50 years •Post traumatic emotional •Increased stress Physical examination in establishing the diagnosis of hyperthyroidism is not only assess the thyroid gland Physical examination may begin with examination on the head and neck . examination begins with an inspection of the thyroid gland in the neck front and side with the patient sitting . Every scar , mass , and distended veins that look to be recorded . After that , palpation of the gland tirod by asking the patient to flex the muscles in the neck so that the neck rather slack palpable thyroid gland of the patient and the presence of the patient Investigation : Although the measurement of blood TSH levels are best screening tool in assessing thyroid function , but the severity of hyperthyroidism less can be judged by the examination . 1. conservative : pharmacotherapy a) Anti-thyroid: to inhibit the formation of thyroid hormones. Drugs Examples: Propiltiurazil (PTU), methimazole (Tapazole) Indications: In hyperthyroid disease. 2. b. non-pharmacological : diet,not comsume alcohol and ciggarettes 3.Operative 1. thyroid storm. Urgent situations characterized high fever, rapid heart rate and irregular (atrial fibrillation), unconscious until death. This condition can occur as a result of taking medications that are not disciplined. 2. abnormality the eye in the form of dry eyes, impaired vision, easy to infection, wound up blind. 3.Hipertensi, heart rhythm disorders to heart failure. 4.Osteoporosis Hyperthyroidism is a condition caused by an excessive secretion of clinical thyroid hormones thyroxine (T4) and triiodothyronine (T3).