Chronic Diarrhea

Definition
= persistent diarrhea

• Diarrheal with or without blood, that begin

acutely and last or least 14 days or longer
which has a different set cause except
infection .
 Pathofsiological mechanisms

- reduced intestinal absorption

- increased intestinal secretion
- altered intestinal motility
 Pathomechanism
• “ prolonged intestinal injury with ineffective
repair mechanism “ ( Lebenthal )
- brush border damage
- villous stunting and flattering
• Deteriorate of defence mechanism ---
bacterial overgrowth :
• - Loss of disaccharidase activity  osmotic D
• - enterotoxin --- secretoric D  water &
electrolyte loss
- Malnutrition -- mucosal can not repaire
 Management Chronic Diarrhea
• - electrolyte- correction of fluid and balance
• - combating life threating infections , like
- sepsis, pneumonia, meningitis,
- nutrititional resitution

• Malnutrition : initial caloric intake :

75 kcal/kg/day - 25 kcal/kg/day 
target  150 kcal/kg/day after 4-5 days