Laktasi

Sherwood Human
Physiology From Cells to
Systems 9e, 2016
 Sherwood Human
Physiology From Cells to
Systems 9e, 2016
Guyton Textbook of Medical
Physiology 13e
Guyton Textbook of Medical
Physiology 13e
 Lactation – Secretion and Ejection of Milk

• Prolactin causes formation and secretion of milk in estrogen- and

progesterone-primed breasts

• Oxytocin causes contraction of myoepithelial cells, leads to milk

ejection through the nipple

• Estrogens increase the number of oxytocin receptors on myoepithelial

cells

• Estrogens (and possibly also progesterone) antagonize the milk

production effect of prolactin
Figure 83–11
Changes in rates of secretion of estrogens, progesterone, and prolactin for 8 weeks before
parturition and 36 weeks thereafter. Note especially the decrease of prolactin secretion back to
basal levels within a few weeks after parturition, but also the intermittent periods of marked
prolactin secretion (for about 1 hour at a time) during and after periods of nursing.
Guyton & Hall Textbook of Medical Physiology 13e