LISTERIOSIS

Outline
￮ Introduction
￮ Incidence
￮ Clinical features
￮ Managements

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1
INTRODUCTION
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￮ Listeria monocytogenes
￮ Aerobic, gram-positive bacillus
￮ Affect people with reduced cell-
mediated immunity (pregnancy)

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2
INCIDENCE
18 times
Higher in pregnant women

1 in 8000
Infection in non-pregnant women

Contaminated food
Source of infection – unpasteurized milk,
ripened soft cheese

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3
CLINICAL FEATURES
1/3 is asymptomatic
￮ Flu-like symptoms
￮ Fever
￮ malaise

Transmission to foetus via ascending route

or trans placentally

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Outcome

20%
Miscarriage

50%
Premature delivery

38%
Neonatal mortality rate – respiratory distress,
fever, sepsis and neurological symptoms
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4
MANAGEMENTS
￮ Diagnosed clinically and isolation from blood, vaginal swabs
￮ Meconium stain liquor in preterm foetus may increase suspicion

￮ Rx - IV ampicillin 2g QID

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