PICO

Intermittent Diazepam vs Phenobarbital to prevent

Recurrence of Febrile Seizure : A Randomized Controlled
Trial
• P : 145 children aged 6mo- 5y.o
• I : Intermittent diazepam
• C : Continuous Phenobarbital
• O : Prevention of recurrent rate of febrile
seizure
Clinical Question
Trial of Amitriptyline, Topiramate, and Placebo
for Pediatric Migraine

• P : 328 migraine pediatric patients

• I : Amitryptilin 1mg/kg/day or Topiramate
2mg/kg/day
• C : Placebo
• O : Reduction in the number of headche
Clinical Question