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Hsci-617 Article Review 1
Hsci-617 Article Review 1
Epidemiology on Pollution
HSCI 617
Erich Bonilla
Rochelle Granados
Juan Landeros
Dolores Mancha
Ana Romero
Vocabulary
❖ (LC) Lung Cancer
❖ (PPB) Parts Per Billion
❖ (PM2.5) Particulate Matter with a diameter > 2.5 micrometers
➢ Human hair is approximately 50-70 micrometers
❖ (IARC) International Agency for Research on Cancer
❖ (AHSMOG) Adventist Health Air Pollution Study
❖ (EPA) Environmental Protection Agency
❖ (O3) Ozone
Learning Objectives
❖ To understand that tobacco smoke, outdoor air pollution, particulate matter
(PM), and diesel exhaust (DE) can all be risk factors in LC.
❖ Assess the association between ambient PM2.5 and LC incidence in a
individual that has never smoked.
❖ Study the independent relationship with ambient O3 in two-pollutant models
with PM2.5 .
Article Citation
❖ Title of Article
➢ The Association between Ambient Fine Particulate Air Pollution and Lung
Cancer Incidence: Results from AHSMOG-2 Study
❖ Journal Details
➢ Environmental Health Perspectives
➢ Volume 123 Number 3 March 2017
1. Lung cancer the leading cause of cancer death?
a. True or False
2. Can you get lung cancer if you have never smoked cigarettes?
a. Yes or No
3. Can air pollution lead to lung cancer?
a. Yes or No
Introduction
❖ Objective
➢ The objective of the study was to assess the association between PM2.5
and risk of Lung Cancer (LC) using the Adventist Health and Smog
Study-2 (AHSMOG-2).
➢ A cohort of health conscious nonsmokers where 81% have never
smoked. Never-smoking participants have been underrepresented in
previous studies.
❖ Hypothesis
➢ Increased exposure to outdoor air pollution (PM2.5) can lead to an
increased incidence of cancer amongst non smokers.
Who Are They?
❖ People
➢ The AHSMOG-2 study, with 80,285 participants, which focused on a large group of
health conscious non-smokers derived from the Adventist Health Study-2.
➢ The AHS-2 study had 96,000 participants between the ages of 30 and 112, who all
identified as adventist.
■ 65% female
■ 65% white (non-hispanic)
■ 26.9% african american
■ 1.1% current smokers
❖ Place
➢ The adventist health study-2 compiled data from all 50 U.S. States and 5 provinces in
Canada
❖ Time
➢ AHS-2 study enrollment occurred from 2000-2007
Method (1)
❖ Design:
➢ Cohort Study
❖ Population Sample:
➢ The AHSMOG-2 study, a large,
health conscious cohort of nonsmokers.
➢ The final analytic study population
consisted of 80,285 participants.
❖ A quantitative study.