Million Health Pharmaceuticals

DESCRIPTION:

 Evermil 10mg is a derivative of Rapamycin
(sirolimus) and works similarly to Rapamycin as an
mTOR (mammalian target of rapamycin) inhibitor.
It is normally used as an immunosuppressant to
prevent rejection of organ transplants.
In a similar fashion to other mTOR inhibitors
Everolimus' effect is solely on the mTORC1 protein
and not on the mTORC2 protein.
Brain carcinoma

 PRESCRIBING
INFORMATION:

 Evermil 10mg tablet are mainly indicated for the
treatment of Renal carcinoma.
Evermil 10mg are mainly indicated for the treatment
of Breast carcinoma.
Evermil 10mg tablet are mainly indicated for the
treatment of Brain carcinoma.
Evermil 10mg is also used in various advanced stage
cancer in stomach, intestines or pancreas.
 MECHANISM OF
ACTION:

 Everolimus is an mTOR prohibitor, joints at high
compatibility to FK506 binding protein 12, via
producing drug complex which inhibits the specific
of mTOR.
This inhibition decreases the activity of effectors
downstream, that may cause blockage of cell
progression from G1 into S phase, subsequently
causes cell growth arrest and apoptosis
PRODUCT
DETAILS:

Brand : Evermil
Ingredients : Everolimus
Strength : 5mg
Manufactured : Glenmark
pharmaceuticals
Package : 10 tablets
 PHARMACOKINETIC:

 ABSORPTION:
 The high plasma concentration time of Everolimus is 1 to
2 hours.The effect of food with Evermil 10mg that with
heavy meal: Reduction of systemic exposure to Evermil
5mg 10mg, and the high blood plasma concentration by
54%.
DISTRIBUTION:
 Evermil 10mg human plasma protein bound with the
range of 74%.
METABOLISM:
 The metabolism of Everolimus is occurred in liver, which
is a substrate of CYP3A4.
The metabolites of Everolimus;
 DOSAGE
MANAGEMENT:

 In breast cancer, renal cell cancer, pancreatic cancer,
Neuro endocrine cancer:
The prescribed dosage is 10mg should be taken as a single
dose.
In Brain or intracranial cancer:
The prescribed dosage of Evermil 10mg tablet is
4.5mg/m2 orally as a single dose.
In pediatric:
The usual pediatric dosage of Evermil 10mg in brain or
intracranial tumor is 4.5mg/m2 should be taken orally as
a single dose.
Evermil 10mg tablet should be administered with or
without food.
 PRECAUTIONS:

 Lymphomas:
 Increased exposure of skin cancers, patient may protect from
UV light
Serious infections:
 Patients receiving Evermil 10mg have high risk of acquiring
various infections related to bacteria, virus, and fungi.
Anti-microbial agents are preferred for the suspected patients.
Hepatic artery thrombosis:
 In liver transplant patients, Evermil 10mg therapy should not
be recommended.
Nephrotoxicity:
 Renal function should be monitored frequently; caution should
be taken while usingEvermil 10mg in renal impaired patients.
 SIDE EFFECTS:

 • Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .
CONTRAINDICATION
S:

 Some anaphylactic reaction occurs, if patients are
contraindicated to the components present in
the Evermil 10mg tablet.
 PREGNANCY:

 Pregnancy category C Evermil 10mg is needed only
by the patients after knowing the benefits to the
mother outweighs the risk to fetus.
 STORAGE :

 Evermil 10mg tablet should be kept at 25°C
Keep the tablet away from moisture, heat and light
Dispense only in original container.
 MISSED DOSE:

 If patient failed to take a single dose, patients must
consult with medical practitioner and follow the
instructions given by them. Or the missed dose
should be avoiding and follow the regular dosing
schedule.
 
 OVERDOSAGE:
 The over dosage of Everolimus is rarely occur, in
case of over dosage patient must be provide with
supportive measures. The acute toxicity of
Everolimus over dosage should be monitored.
 CONTACT US:

 PHONE NO:+91-9940472902

 E-MAIL:millionhealthpharmaceuticals@gmail.com

 WEBSITE URL:https://millionpharma.com/evermil-10-mg.php