BDENZA 40MG CAPSULES

(ENZALUTAMIDE) |APPLE
PHARMACEUTICALS

DOSING CONDITIONS AND ADMINISTRATION

PHARMACOKINETICS
MECHANISM
DISTINCTLY IN
WARNING AND PRECAUTIONS
MISSED DOSE
CONTRAINDICATION
SIDE EFFECTS
CONTACT DETAILS
• Bdenza 40mg is a hormonal therapy, for men who are all affected
with prostate carcinoma in metastatic stage. Bdenza 40mg
capsules are majorly indicated for prostate carcinoma, which
contains Enzalutamide, as an active component considered as non
steroidal anti-androgen medication .Bdenza 40mg is involved in
association with castration in the therapy of metastatic or long
lasting castration resistant prostate cancer. .Bdenza 40mg is a
prescription medicine, the main ingredient which is used as
enzalutamide, only prescribed by medical oncologist.
DOSING CONDITIONS AND
ADMINISTRATION

• The usual prescribed dosage of Bdenza is 160mg as a single

dose by taking with or without food. .Bdenza 40mg is available
in the strength of 40mg; four capsules of Bdenza 40mg should
be administered at a same time Bdenza 40mg capsules should
not crush, not chew taken with glass of water. Dose adjustment:
In patients with ≥ grade III toxicity:
• Bdenza 40mg therapy should be refuse for one week or the
symptoms should be reduced to grade II, then restart with same
dose or decreased to 80mg or 120mg Strong CYP2C8
inhibitors:
• While combining with Bdenza 40mg capsules, the dosage should
be modified by reducing to 80mg as a single dose or avoid this
combination. Strong CYP3A4 inducers: Co administration
of Bdenza 40mg with Strong CYP3A4 inducers, the dosage
of Bdenza 40mg capsules increased up to 240mg or stop this
combination.
 PHARMACOKINETICS
Absorption:
• After receiving 160mg of Bdenza 40mg for mCRPC, from median time to attain peak
plasma concentration time at 1 hour (variation with 0.5 to 3 hours). The steady state
level of Bdenza 40mg is accomplished by day 28 Food does not cause any alteration in
absorption of Bdenza 40mg capsules.

Distribution:
• Volume of distribution 110L High plasma protein bounding capacity of Bdenza
capsules is occurs as 97% to 98%
Metabolism:
• Two most prominent cytochrome isoenzymes are involved in metabolism of Bdenza
capsules; There are two isoenzymes i.e CYP2C8 & CYP3A4; in which CYP2C8 is
vital for production of N-desmethyl Enzalutamide which is an active metabolite of
Enzalutamide.

Excretion:
• Bdenza capsules undergoes excretion by hepatic metabolism Major route of
elimination; 71% in urine; 14% in feces The terminal half life period of Bdenza
capsules is 5.8 days (range at 2.8 to 10.2 days); N-desmethyl Enzalutamide has
half life period of relatively 7.8 to 8.6 days.
 MECHANISM

• An androgen which is a male hormone is used to develop prostate

carcinoma. One of the major hormone secreted by testes and
adrenal glands is known as testosterone. Bdenza containing
Enzalutamide will interfere with testosterone production, causes
tumor cell growth depletion. Bdenza interfere with androgen
receptor signaling transduction and leads to cancer cell lysis
 DISTINCTLY IN

Pregnancy :
• Pregnancy category of Bdenza capsule is D Bdenza is
contraindicated to pregnancy; it may cause fetal harm even to
death.
Lactation :
• Breast feeding is not suggested, Bdenza 40mg is contraindicated
in lactation
 WARNING AND PRECAUTIONS

Bdenza 40mg

• During the treatment with Bdenza 40mg capsules, patient may suffer with some
adverse effects like; Posterior reversible encephalopathy syndrome Seizures In
PRES, some neurological disorders occur in patients. The condition can
recovered by providing safety measures or discontinue the therapy as soon as
possible. PRES is recognized by using MRI In seizures, Before starting the
treatment patient must counsel about this adverse reaction and Stop the therapy
if possible. Spermatogenesis occurs that may prohibit the male fertility leads to
hypo spermatogenesis. In androgen decline the treatment, may have increase
exposure of cardiovascular disease like worsening hypertension.
 MISSED DOSE

• Bdenza 40mg is a chem. Drug, used in prostate cancer. Bdenza

40mg capsule should not be self medicated, used by the
patients only after getting advice from the medical oncologist. If
a single dose missed by patient, then must consult with the
physician and follow the instructions as per the guidance of
medical adviser, the missed dose should be taken within a time
or avoid the missed dose and follow the regular schedule.
 CONTRAINDICATION

• Bdenza 40mg capsules are contraindicated to pregnancy

condition, which may cause fetal harm leads to death. An
Anaphylactic reaction happens, if patients are contraindicated to
the ingredient present in Bdenza capsules.
 SIDE EFFECTS

• Some side effects during the therapy using with Bdenza 40mg ;
Back pain, Arthralgia, Muscular weakness, pain, Diarrhea,
Hypertension & hot flush, Dizziness, headache, Asthenia
conditions, Peripheral edema, Spinal cord compression,
paresthesia, Mental impairment, Hypesthesia, Respiratory tract
infections, Hematuria, Pollakiuria, Dry skin, Pruritus,
Neutropenia, Thrombocytopenia, Increasing bilirubin level,
Epistaxis, Infections like sepsis,Hallucinations , Fractures, joint
injury, and hematomas (Fall associated injuries).
CONTACT DETAILS

Phone : 9987711567
Email : applepharmaceutical@gmail.com
Email : info@myapplepharma.com
Website: https://myapplepharma.com/enzalutamide.php
https://myapplepharma.com/bdenza-40mg.php