SINDROM METABOLIK

I WAY AN SUWARNA
Source: International Chair on Cardiometabolic Risk
www.cardiometabolic-risk.org
 Economic and humanistic burden of chronic diseases

http://www.who.int/chp/chronic_dise
ase_report/en/index.html

Source: International Chair on Cardiometabolic Risk

www.cardiometabolic-risk.org
 Common risk factors for chronic diseases

Deaths from 4 chronic diseases

Tobacco Poor diet Lack of exercice

3 risk factors

Deaths from all other causes

50% of all deaths

Chronic respiratory
Cardiovascular disease Type 2 diabetes Cancer

4 chronic diseases

Source: International Chair on Cardiometabolic Risk Oxford Health Alliance 2003

www.cardiometabolic-risk.org
 Same Body Mass Index, Higher Risk for Diabetes in
Asians
1970-1989
Obesity
Multiplication factor for increased Prevalence of type 2 diabetes (%)

Prevalence of type 2 diabetes (%)

1990-2005
14
Overweight

12 70

10 60

50
8
40
6
30
4
20
2 10

0 0

Prevalence of type 2 diabetes (%)

prevalence of type 2 diabetes

6
14
5 12

4 10

8
3
6
2
4

1 2

0
0

s
a

nd
e
A

a
ng

a
an
ne
di

or
in

re
a
na

an
SA

ia

nd

US
e
a

la
Ko
iw
di

or
re

In

Ch

ap
es

Ko
pi
hi

la

iw

ai
In
U

Ta
ap
Ko

ilip

ng
C
n

ai

ng

Th
Ta
do

ng
Th

Ph

Si
Ho
In

Si

Source: International Chair on Cardiometabolic Risk Adapted from Yoon KH et al. Lancet 2006; 368: 1681-8
www.cardiometabolic-risk.org Reproduced with permission
 Definition of Metabolic Syndrome

According 2001 NCEP/ATP III, the criteria to define

metabolic syndrome are presence of any three of the
following five traits:

– Abdominal obesity, defined as waist circumference in men > 40

inches and women > 35 inches
– Serum triglycerides ≥ 150 or drug treatment for elevated
triglycerides
– Serum HDL cholesterol < 40 mg/dl in men and < 50 mg/dl in
women or drug treatment for low HDL-C
– Blood pressure ≥ 130/85 mmHg or drug treatment for elevated
blood pressure
– Fasting plasma glucose ≥ 100 mg/dl or drug treatment for
elevated blood glucose

Source: International Chair on Cardiometabolic Risk

www.cardiometabolic-risk.org
Obesity, Type 2 Diabetes, Hypertension or Dyslipidemia

Relative risk

Waist circumference (cm)

Source: International Chair on Cardiometabolic Risk Adapted from Lee ZSK et al. Obes Rev 2002; 3: 173-82 and
www.cardiometabolic-risk.org Ko GT et al. Int J Obes Relat Metab Disord 1997; 21: 995-1001