PERAN ION KALSIUM

Figure 20-15a The Action Potential in Skeletal and Cardiac Muscle

Rapid Depolarization The Plateau Repolarization

Cause: Na+ entry Cause: Ca2+
entry Cause: K+ loss
Duration: 3–5 msec Duration: ~175 msec Duration: 75 msec
Ends with: Closure of Ends with: Closure Ends with: Closure
voltage-gated fast of slow calcium of slow potassium
sodium channels channels channels

mV Relative
refractory
Absolute refractory period
period

Stimulus Time (msec)

Events in an action potential in a ventricular muscle

cell.

KEY
Absolute refractory
period

Relative refractory
period
HIPOKALSEMIA
• Kadar diplasma : 4,5-5,5 Meq/l (8,5-10,5 mg/dl)
• Berperan dalam : neuromusculat transmisi,kontraksi otot
jantung, koagulasi.
• Hipoalbumin,hipoparatiroid, pancreatitis akut, defisiensi
vitamin D, malabsorbsi
HIPERKALSEMIA
• Hiperparatiroid, malignancy.