Liquifactive

Necrosis
Presenter- Deepthi Sarah Alex
 Topic outline
• Cell injury
• Cell Death
• Necrosis
• Types of necrosis
• Liquifactive necrosis
Cell injury
 Necrosis
• Cell death
• Denaturation of intracellular proteins
• Lysosomal Enzymatic digestion
• Inflammatory response
 Types of Necrosis-
morphological
• Liquefactive
• Coagulative
• Caseous
• Fat
• Fibrinoid
 LIQUEFACTION
(COLLIQUATIVE) NECROSIS

• Pattern of necrosis
• Degradation of tissue into a liquid viscous mass (Pus)
Ex – ischaemic / infective injury of brain ,
- Focal Bacterial/ fungal infection in solid organs
 Pathophysiology
• Release of enzymes ( from the dying cells,
inflammatory cells)

• Three major factors contribute to liquefactive necrosis:

-Enzymatic digestion of dead or dying tissues.
-Enzymatic digestion of surrounding tissues.
-Denaturation of cellular proteins.
Enzymes involved in liquefaction includes:
• Proteases (Collagenases, elastases),
• DNases
• Lysosomal enzymes
Gross
 Microscopy
• cell debris , neutrophils, macrophages
• Brain- cyst wall – proliferating glial cells
• abscess cavity -proliferating
Thankyou