Hyaluronidase (Human Recombinant)

Molecular Weight (Daltons) : 61000

• Description
A purified preparation of the enzyme recombinant human
hyaluronidase. Hyaluronidase (Human Recombinant) is produced
by genetically engineered Chinese Hamster Ovary (CHO) cells
containing a DNA plasmid encoding for a soluble fragment of
human hyaluronidase (PH20). The purified hyaluronidase
glycoprotein contains 447 amino acids with an approximate
molecular weight of 61,000 Daltons.
• Indication
Indicated as an adjuvant to increase the absorption and dispersion
of other injected drugs; for hypodermoclysis; and as an adjunct in
subcutaneous urography for improving resorption of radiopaque
agents.
• Pharmacodynamics
Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion
of injected drugs, thus facilitating their absorption. Hyaluronidase
is used for enhancing absorption and distribution of other
injected drugs.
• Mechanism of Action
The family of hyaluronidase enzymes hydrolyzes hyaluronic acid
(a glucoseaminoglycan) which is a major constituent of the
interstitial barrier. Hyaluronidase (Human Recombinant) is a
highly purified recombinant human hyluronidase which lowers
the viscosity of the interstitial barrier by breaking down
hyaluronic acid and is under investigation as a chemoadjuvant to
facilitate local interstitial drug delivery as well as increase
bioavilability.
• Targets
Hyaluronan; Transforming growth factor beta-1
• Useful links
• http://www.rxlist.com/rhogam-ultra-filtered-plus-drug/clinical-
pharmacology.htm