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Pathophysiology

• Treponema pallidum penetrates intact mucous membranes or


microscopic dermal abrasions and within hours enters lymphatics and
blood to spread troughout the body.
• It attaches to the endothelial lining of blood vessels causing
inflammation – endarteritis.
• Later there can be hyper-sensitifity response to the organism
resulting in gummatous lesions and necrosis.
Pathophysiology

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