Treponema pallidum bacteria enter the body through small cuts or mucous membranes and spread through the lymphatic system and bloodstream. It attaches to blood vessel linings, causing inflammation of these vessels. Later, an immune response to the bacteria can form gummas and cause tissue death in severe cases.
Treponema pallidum bacteria enter the body through small cuts or mucous membranes and spread through the lymphatic system and bloodstream. It attaches to blood vessel linings, causing inflammation of these vessels. Later, an immune response to the bacteria can form gummas and cause tissue death in severe cases.
Treponema pallidum bacteria enter the body through small cuts or mucous membranes and spread through the lymphatic system and bloodstream. It attaches to blood vessel linings, causing inflammation of these vessels. Later, an immune response to the bacteria can form gummas and cause tissue death in severe cases.
• Treponema pallidum penetrates intact mucous membranes or
microscopic dermal abrasions and within hours enters lymphatics and blood to spread troughout the body. • It attaches to the endothelial lining of blood vessels causing inflammation – endarteritis. • Later there can be hyper-sensitifity response to the organism resulting in gummatous lesions and necrosis. Pathophysiology