MD MODASSIR ANWER

ROLL NO- M4NST1709

Under the guidance of

DR. MAHUA GHOSH CHAUDHURI
Faculty of Interdisciplinary Studies, Law and
Management Jadavpur University
 INTRODUCTION
Drug delivery:
 Drug delivery alludes to approaches, formulations,
innovations, technologies, and system for
incorporating a pharmaceutical compound in the
body. It might involve scientific site targeting
within the body.

Drug Carrier:
 A drug carrier is used in the drug delivery process
which serves to improve the selectivity,
effectiveness and safety of drug administration.
 Nano-drug carrier extends biological half life of
drug.
Burst Release:
 Burst release dosage forms are design to release a drug over short
interval of time.
 Burst release is rapid release or high initial rates of delivery.

Sustained Release:
 Sustained release dosage forms are designed to release a drug at a
predetermined rate by maintaining a constant drug level for a
specific period of time with minimum side effects.
 Sustain release implies slow release of the drug over a time
period.
 Advantage of sustained drug delivery over conventional dosage
forms like
a. Maximum utilization of drug.
b. Better control of drug absorption can be attained.
Kinetic model:
Zero order:
Qt =Q0+ kt

First order:
Kt
log 𝐶 = 𝑙𝑜𝑔𝐶0 −
2.303

Higuchi model:
𝑄 = 𝐾H 𝑡

Korsmeyer-Peppas model:
𝑀𝑡
= 𝐾𝑡 𝑛
𝑀∞
 OBJECTIVE
Synthesis of silica gel in two different ratio by using
TEOS: ETOH: DI WATER in 1:2:1 and 1:2:2 ratios by sol
gel process.

Entrapment of Ibrufen in mesoporous Silica gel to

study the release of Ibrufen in Simulated Body Fluid
(SBF).

Characterization of Ibrufen entrapped silica gel using

XRD, FTIR & FESEM.

Study of burst and sustained release kinetics of Ibrufen

in Simulated Body Fluid (SBF) using UV-Vis
spectroscopy.
 METHODLOGY
Silica gel is synthesized using TEOS, ETOH and DI Water
as a precursor in the ratio of 1:2:1and 1:2:2.
Silica gel is characterized using XRD and FESEM. From
XRD the phases of the sample are revealed and from
FESEM analysis the morphology of silica gel is found.
Entrapment of Ibrufen in the Silica gel matrix is carried
out at room temperature and characterized by FTIR.
SBF of pH 7.0 is prepared.
Release of silica gel entrapped Ibrufen is carried out in
SBF using UV-Vis.
The kinetic study of release mechanism is analyzed.
Entrapment of Ibrufen with Silica gel matrix of TEOS:
ETOH: DI WATER:
Drop wise
added
DI WATER + C2H5OH Ibuprofen + TEOS +
C2H5OH

Stirring at room
temperature

Silica gel with Silica sol with

entrapped Ibuprofen Drying at room Ibuprofen
temperature
for 7 days

Characterization using Study of release kinetic of

XRD, FTIR, FESEM Ibrufen in SBF
Preparation of Simulated body Fluid formation:
 750ml of ultra-pure (DI) water was taken.
 Ingredients were measured in an electronic weighing machine.
 Added water by the use of magnetic stirrer one by one according the
table.
 At last pH of SBF was measured 7.0.
Reagents SBF for 1litre
(wt.in gram)
NaCl 7.996
NaHCO3 0.35
KCl 0.224
K2HPO4 .3H2O 0.228
MgCl2.6H2O 0.305
1 Kmol/mᵌ HCl 40 cmᵌ
CaCl2 0.278
Na2SO4 0.071
(CH2OH)3CNH2 6.057
Ultra-Pure water 750ml
 RESULT & DISCUSSION
XRD analysis:

 These two figure represents the XRD pattern of bare silica gel in two different ratio
e.g., TEOS: ETOH: DI WATER (1ml: 2ml: 1ml) & (1ml: 2ml: 2ml).
 Hump in between 150-250 indicates the presence of amorphous silica.
 No other peak is present, which indicates pure amorphous silica.
FESEM analysis:

 FESEM of bare silica gel of TEOS: ETOH: DI WATER in (1:2:1) ratio.

 FESEM of bare silica gel of TEOS: ETOH: DI WATER in (1:2:2) ratio.

 FTIR analysis:
 Solid Ibrufen entrapped in Silica gel matrix of TEOS: ETOH: DI WATER
(1:2:1) ratio: Bare Solid Silica
silica Ibrufe gel
gel n entrap
1:2:1 ped
Ibrufen
Wavenum Vibrati Wavenum Vibrati Wavenum Vibratio
ber (cm-1) on type ber (cm-1) on type ber (cm-1) n type
457 Si-O-Si 786 C-H 457 Si-O-Si

793 Si-O-Si 1231 C-O 785 C-H

966 Si-OH 1712 C=O 966 C=C

1090 Si-OR 2956 C-H 1048 CO-O
1629 C=O 3607 OH 1629 C=C
3328 OH 1712 C=O
 Peaks at 457 and 793 cm-1 are 3330 OH
found for the Si–O–Si bending
vibration & peak at 1,090 cm-1 is for the Si–OR stretching vibration in silica gel.
 Peaks at 1511 cm-1 & 1712 cm-1 are present in the FTIR data of Ibrufen is also present in the
FTIR data of loaded silica gel.
 These two peaks are absent in the FTIR data of bare silica gel. This indicates the presence of
Ibrufen in silica gel.
Solid Ibrufen entrapped in Silica gel of TEOS: ETOH: DI WATER (1:2:2)
ratio: Bare Solid Silica
silica Ibrufe gel
gel n 1:2:2 entrap
ped
Ibrufen
Wavenum Vibrati Wavenum Vibrati Wavenum Vibratio
ber (cm-1) on type ber (cm-1) on type ber (cm-1) n type

457 Si-O-Si 775 C-H 457 Si-O-Si

793 Si-O-Si 1225 C-O 793 C-H

966 Si-OH 1720 C=O 959 C=C

1090 Si-OR 2956 C-H 1086 CO-O

1629 C=O 1629 C=C

3328 OH 1725 C=O

3330 OH

 Peak at 1720 cm-1 present in the FTIR data of Ibrufen is also present in the FTIR data of
loaded silica gel at 1725 cm-1. This peak is absent in the FTIR data of bare silica gel.
This indicates the presence of Ibrufen in silica gel.
Liquid Ibrufen entrapped in Silica gel of TEOS: ETOH: DI WATER (1:2:1)
ratios: Bare Liquid Silica
silica Ibrufe gel
gel n 1:2:1 entrapp
ed
Ibrufen
Wavenum Vibrati Wavenum Vibrati Wavenum Vibratio
ber (cm-1) on ber (cm-1) on type ber (cm-1) n type
type
457 Si-O-Si 802 C-H 457 Si-O-Si

793 Si-O-Si 1157 C-O 802 C-H

966 Si-OH 1657 C=O 966 C=C

1090 Si-OR 3553 OH 1090 CO-O

1629 C=O 1629 C=O

3328 OH 3354 OH

3330 OH

 Two peaks at 802 cm-1 and 1657 cm-1 present in the FTIR data of Ibrufen is also present
in the FTIR data of loaded silica gel at 798 cm-1 and 1638 cm-1 .These two peaks are
absent in the FTIR data of bare silica gel. This indicates the presence of Ibrufen in silica
gel.
Liquid Ibrufen entrapped in Silica gel of TEOS: ETOH: DI WATER (1:2:2)
ratio:
Bare Liquid Silica
silica Ibrufe gel
gel n 1:2:2 entrap
ped
Ibrufen
Wavenum Vibrati Wavenum Vibrati Wavenum Vibratio
ber (cm-1) on ber (cm-1) on type ber (cm-1) n type
type
457 Si-O-Si 802 C-H 456 Si-O-Si

793 Si-O-Si 1166 C-O 796 C-H

966 Si-OH 1712 C=O 962 C=C

1090 Si-OR 3559 OH 1090 CO-O

1629 C=O 1712 C=O

3328 OH 3324 OH

 Peak at 1712 cm-1 are present in the FTIR data of Ibrufen are also present in the FTIR
data of loaded silica gel. This peak is absent in the FTIR data of bare silica gel. This
indicates the presence of Ibrufen in silica gel.
UV-Vis spectroscopy analysis:

 Standard curve of liquid Ibrufen and solid Ibrufen .

 The R2 value of liquid Ibrufen is 0.99 and solid Ibrufen is 0.99.

Kinetic study of drug release:
Burst release of liquid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in (1:2:1)
ratio:

Model Zero order First order Higuchi Korsmeyer- Best fitted for
Peppas burst release

R2 value 0.97316 0.96993 0.94419 0.89867 Zero order

n=1.54
Burst release of liquid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in (1:2:2)
ratio:

Model Zero order First Higuchi Korsmeyer- Best fitted for burst
model Peppas release

R2 value 0.9793 0.94018 0.92636 0.88117 Zero order

n=1.38
Burst release of Solid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in (1:2:1)
ratio:

Model Zero First Higuchi Korsmeyer Best fitted for burst

order order -Peppas release

R2 value 0.979 0.959 0.9631 0.96811 Zero order

n=1.99
Burst release of Solid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in (1:2:2)
ratio:

Model Zero order First order Higuchi Korsmeyer- Best fitted for
Peppas burst release

R2 value 0.96969 0.93777 0.9176 0.8741 Zero order

n=1.34
Sustained release of Liquid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in
(1:2:1) ratio:

Model Zero First Higuchi Korsmeye Best fitted for

order order r-Peppas sustain release
R2 value 0.9897 0.974 0.9737 0.9535 Zero order

n= 1.78
Sustained release of Liquid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in
(1:2:2) ratio:

Model Zero First Higuchi Korsmeyer- Best fitted for

order order Peppas sustain release

R2 value 0.98276 0.9634 0.937 0.9245 Zero order

n=1.68
Sustained release of Solid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in
(1:2:1) ratio:

Model Zero order First order Higuchi Korsmeye Best fitted for
r-Peppas sustain release

R2 value 0.992 0.982 0.986 0.968 Zero order

n=1.99
Sustained release of Solid Ibrufen entrapped in Silica of TEOS: ETOH: DI WATER in
(1:2:2) ratio:

Model Zero order First order Higuchi Korsmeyer- Best fitted for
Peppas sustain release
R2 value 0.99127 0.97169 0.9738 0.9648 Zero order
n=1.984
 CONCLUSION
 Silica gel is synthesized by using TEOS: ETOH: DI WATER
by sol gel process. It is then successfully loaded with solid
and liquid Ibrufen. The entrapment of drug in silica gel is
confirmed by FTIR.

 XRD pattern and FESEM microphotographs shows the fine

size of the silica gel.

 Release of Ibrufen from silica gel to SBF is studied.

 Kinetics study of burst and sustained release of solid and

liquid Ibrufen in SBF is carried out. It is found to follow
the zero order mechanism for both types of gel for both
solid and liquid Ibrufen.