Nanotechnology

Trends in Nanotechnology for drug

delivery
Presented by:
Ronaldo Dixon 1301284
Adrian Fagan 1301500
 Trends in Nanotechnology for drug delivery

Objectives

• Design of nanoparticles

• Mechanism of delivery in animals/humans

• Analysis/detection of nanoparticles
 Trends in Nanotechnology for drug delivery

Definitions and key terms

• Nanotechnology- Nanotechnology ("nanotech") is the

manipulation of matter on an atomic, molecular, and
supramolecular scale.

• Nanomedicine- Nanomedicine is the medical use of

molecular-sized particles to deliver drugs, heat, light or other
substances to specific cells in the human body
 Trends in Nanotechnology for drug delivery

History/background of nanotech for drug delivery

• Richard Feynman & the Nobel Prize in Physics (1965).

A key date for nanotechnology and more specifically for

nanotechnology applied to medicine is the year 1959,
when Richard Phillips Feynman pointed out the promise and
potential of nanotechnology in his historic lecture.
 Trends in Nanotechnology for drug delivery

History/background of nanotech for drug delivery

•Nanomedicine is the monitoring, repair,
construction, and control of human biological
systems at the molecular level using engineered
nanodevices and nanostructure

•Currently, several university and industrial research

groups are developing medical applications for
nanotechnology.
 Trends in Nanotechnology for drug delivery
Design of nanoparticles

Types of nanoparticles:

• Liposomes • nanoparticles
• Metal nanoparticles • Nanowire
• Dendrimers • Polymeric nanoparticles
• Fullerenes • Nanotubes
• Quantum dots • Quantum dots
• Magnetic • Nanoshells
• Cantilevers • Nanorobots
Trends in Nanotechnology for drug delivery
 Trends in Nanotechnology for drug delivery

Mechanism of delivery in animals/humans

 Trends in Nanotechnology for drug delivery

Analysis/detection of nanoparticles
Targeted Drug Delivery
Targeting Ligands
 Nanoparticles for Drug Delivery
• Metal-based nanoparticles

• Lipid-based nanoparticles

• Polymer-based nanoparticles

• Biological nanoparticles
 Nanobiopharmaceuticals
• In biopharmaceuticals, in addition to the
main technologies covered-liposomal,
monoclonal antibody-based, and
polymer-based technologies host of
newer technologies such as
nanoparticles including various
nanodimensional entities such as
molecular imprinted polymers,
metallofullerenes, prodrug delivery, oral,
injectable and implantable, pulmonary,
and transdermal and transmucosal
delivery have come up.
 Drug Delivery Technology Important
to Pharma Industry

• Drug delivery formulations involve low cost

research compared that for discovery of new
molecule,

• Minimizing the drug use would significantly

reduce the effective cost of drug which would
give financial relief to the patients,
 Drug Delivery Technology Important
to Pharma Industry
• Delivery systems increase commercial
opportunity by distinguishing a drug from
competitive threats posed by “me too” drugs
and

• Novel means of delivery particularly using

nano-carriers, can allow branded drugs to be
rescued from abyss of generic competition
(may be called “resurrection of drug”).
 SOME SIGNIFICANT ACHIEVEMENTS
OF NANODEVICES
• Development of one dose a day ciprofloxacin
using nanotechnology

• Tumor targeted taxol delivery using nanoparticles

in Phase 2 clinical trial stage

• Improved ophthalmic delivery formulation using

smart hydrogel nanoparticles

• Oral insulin formulation using nanoparticles

carriers.

• Liposomal based Amphotericin B formulation

 CHALLENGES

• Prevention of drug from biological degradation

• Effective Targeting

• Patient Compliance

• Cost effectiveness

• Product life extension

Future Possiblities: Oxygen Selective
Pump

http://www.foresight.org/Nanomedicine/
 Respirocytes: A Mechanical Artifical
Red Blood Cell

•Bloodborne spherical 1-micron diamondoid 1000-atm pressure vessel

•Active pumping powered by endogenous serum glucose
•Able to deliver 236 times more oxygen to the tissues per unit volume than natural red
cells and to manage carbonic acidity

http://www.foresight.org/Nanomedicine/Respirocytes.html
Fixing Damaged Blood Cells

http://bionano.rutgers.edu/mru.htm
 Conclusion

• Currently, a variety of research is being

performed on nanomedical devices.
• Few industrial products exist right now.
• The possibilities are endless, but will take time
to develop.
 Sources

• http://www.foresight.org/Nanomedicine/
• http://news-info.wustl.edu/tips/page/normal/203.html
• http://wtec.org/loyola/nano/IWGN.Research.Directions/
• http://www.foresight.org/EOC/
• http://www.nanobmi.com/
• http://www.nano.me.berkeley.edu/
• http://bionano.rutgers.edu/mru.html