Dopamin

Cindy
• The tuberoinfundibular system projects from cell
bodies in the hypothalamus to the pituitary stalk,
exerting inhibitory control over prolactin secretion.
• The nigrostriatal system originates from cell bodies in
the substantia nigra and projects to the basal ganglia,
regulating involuntary motor activity.
• The cell bodies of the mesolimbic pathway are located
in the ventral tegmentum and project diffusely to the
nucleus accumbens, amygdala, hippocampus, medial
dorsal nucleus of the thalamus, and cingulate gyrus.
This pathway modulates emotional expression,
learning and reinforcement, and hedonic capacity.
• The fourth DA pathway, also originating in the
ventral tegmentum, is the mesocortical pathway,
which projects to the orbitofrontal and the
prefrontal cortical regions. The mesocortical
pathway helps regulate motivation,
concentration, and initiation of goal-directed and
complex executive cognitive tasks.
• Across pathways, increased DA activity is
potentiated by nicotinic inputs and
glucocorticoids, and DA levels are inversely
correlated with indices of brain 5-HT activity.
 Dopamine and Depression
• Decreased mesocortical and mesolimbic DA
activity has obvious implications in the
cognitive, motor, and hedonic disturbances
associated with depression and is a target for
action for some investigational compounds.
• The Dopamine D1 receptor may be hypoactive
in depression
• Dopamin >>  Manic
Amfetamin, Tyrosine, Bupropion
• Dopamin <<  Depresi
Reserpine, Parkinson