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Hypo THR Roid
Hypo THR Roid
• ACQUIRED
Iodine deficiency
Auto-immune thyroiditis
Thyroidectomy or RAI therapy
TSH or TRH deficiency
Medications (iodide & Cobalt)
Idiopathic
KILPATRIK GRADING OF GOITRE
• Overt obesity
• Myopathy & rheumatic pains
• Speech disorder
• Impaired night vision
• Sleep apnea (central & obstructive)
• Anasarca
• Achlorhydria & low intrinsic factor
OCCASIONAL FEATURES (2)
• Decreased bone turnover
• Decreased VIII, IX & platelets adhesion
• Decreased GFR & hyponatremia
• Hypertension
• Increased levels of CK, LDH & AST
• Abnormal EEG & high CSF protein
• Psychiatric manifestations
ASSOCIATIONS
FOOD
Soybeans
Millet
Cassava
Cabbage
CLINICAL FEATURES (4)
Neurological manifestations
Hypotonia & later spasticity
Lethargy
Ataxia
Deafness + Mutism
Mental retardation
Slow relaxation of deep tendon jerks
CONGENITAL HYPOTHYRODISM