Physiology of Kidney

(Urinary System)
Sri Redjeki
Dept. of Biomedical Sciences
UKI
The Kidney
Function:
Maintains the stable internal environments (the ECF) necessary for the
cells to perform their various activities.
Kidney controls
• Volume
• Electrolyte composition
• Total body fluid volume
• Acid-base balance
• Blood pressure
Kidney excretes
• Endogenous wastes: urea, creatine, uric acid and bilirubin
• Exogenous substances: drugs and their metabolites
Components of Urinary system
Anatomy of the Kidney
the Nephron = the functional unit
Nephron & kidney blood vessels
Functions of the Nephron
The control processes
• Filtration – function of the glomeruli
• Reabsorption – function of the tubules
• Secretion – function of the tubules
Filtration: Glomerulus
Filtrating membrane of glomerulus
Filtrating membrane of glomerulus
Filtration: the effect of blood volume in the glomerulus
Filtration pressure
Glomerular Filtration Rate (GFR)

GFR = KF x Net filtration pressure

Kf – filtration coefficient (quality of filtration

membrane
Reabsorption & Secretion: the tubules
Reabsorption
Secretion
Reabsorpsi dan sekresi
Water balance
Vasopressin/ADH
Vasopressin/ADH
Vasopressin/ADH
Electrolyte balance
Control of blood pressure:
Renin-Angiotensin-Aldosteron System
Renin
Aldosterone
Homeostasis maintaining ECF volume
Urine formation
Acid–base balance
Acid–base balance
Micturition
Tegangan Vesika Urinaria
 SUMMARY
 FILTRATION • ECF volume
 SECRETION • electrolyte
 REABSORPTION • total body fluid volume

o SECRETION
Acid-base balance
o REABSORPTION

RENIN PRODUCTION
Control of blood pressure
(renin-angiotensin-aldosterone system)
SUMMARY
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