CLINICAL QUESTION

USING PICO
 PICO FORMAT

 P: children aged 6mo – 5 y.o with Febrile

Seizure in Amirkola Children’s Hospital
 I: Intermittent diazepam
 C: Continuous Phenobarbital
 O: recurrence of Febrile Seizure
 CLINICAL QUESTION

Which is more effective for prevent

recurrence of febrile seizure,
continuous phenobarbital or
intermittent diazepam?
 PICO FORMAT
 P: Childreen & adolescent 8 to 17 yo with
migraine
 I :Amitryptilin (1mg/kg/day) or
Topiramate (2mg/kg/day)
 C: Placebo
 O: primary : Reduction of headache
secondary: emerging of headache-related
disability, headache days, adverse event
 CLINICAL QUESTION

Which medication is best to

reduction of headhache in
pediatric and adolescent
migraine, amitriptyline or
topiramate or placebo ?