Osteoporosis

Yulyani Pratiwi
Preceptor : dr. Langga S. Sp.OT
Abnormally low bone mass and
defects in bone structure
 Osteo = bones
Porosis = pores
Breakdown > formation in porus bone
Spongy bone : 3-4 years
Compact bone : 10 years

Bone Remodeling
1. Bone Resorption
2. Bone Formation
Serum Calcium levels
1. PTH  resorption
2. Calcitonin  bone formation & decrease bone resorption
3. Vitamin D  increase uptake of calcium

- Genetics (African)
- Nutrition
- Strength training
- Estrogen and androgen
 Pathology

Fewer Thinning Widened Havesian

Trabeculae Cortical Bone Canal
 Low Estrogen and Serum Calcium

Risk Factor Diseases (Turner Syndrome, Hyperprolactinemia, Klinefelter Syndrome,

Cushing Syndrome, Diabetes Mellitus)

Alcohol and Smoking Consumption

Physical Inactivity

Drugs (glucocorticoids, heparin, L-thyroxine)

 Two Types

Postmenopausal Senile

↑ resorption ↓ work of
osteoblast
 Clinical
Manifestation
Common Osteoporotic Fracture

Hip Wrist
Spine

700.000 / 300.000 / 200.000 /

year year year
 Diagnosis

Dual Energy X-Ray Absorptiometry

(DEXA) Scan
 Treatment
Bisphosphonates
Alendronate, Risendronate

01

Thiazide Diuretic Advanced: Teriparatide

Decrease mineral bone loss by Recombinant PTH, Increase
increasing calcium retention 05 02
bone formation

Denosumab 04 03 Raloxifene
Monoclonal Antibody Selective Estrogen Receptor
Modulator
Thank You