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Saliva Lead Levels in Blue Collar Workers

from Different Industrial Areas in Palestine

Presented by:
Omar Naseef 11243711
Kamil Muwafi 11210418
Abdullah Matar 11243935

Supervised by
Dr. Ramzi Shawahna
Dr. Ahed Zyoud
Introduction
 Lead is one of the most toxic heavy metals known
around the world.
 Lead can be found in many sources that we are daily
exposed to, such as drinking water, tobacco and even
soil.

 Chemicals like paintings, hennas, pottery, bullets are


other sources.
Our Study

 Our study aims to assess the levels of lead in


saliva samples from blue collar workers in
different industrial areas in Palestine, and to
investigate which sociodemographic and
occupational characteristics were associated
with lead levels.
 Target Population

 Blue collar workers in mines, metal and chemical


factories, mobiles and car repair workshops, paintings
and gasoline exposure occupations.
Methods
 Study participants were 97 blue collar workers from
different industrial zones in Palestine (Nablus, Jenin,
Tulkarm and Qalqilyah), who were visited in their
workplaces in the time between October 2017 and
February 2018.
 For each worker, 5 ml saliva was collected using
polyethylene tubes, along with a questionnaire for
some related factors, and a consent form.
Questionnaire
Ethical Approval
 All aspects of the study
protocol were authorized
by the Institutional
Review Boards (IRBs) of
An-Najah National
University before the
beginning of data
collection.
Analytical procedure

inductively coupled plasma mass spectrometry (ICP-MS)


 The median saliva lead level in this study was 1.84
µg/L with an IQR of 5.04 µg/L

 World Health Organization’s accepted limits of lead in


breast milk ranges from 2.0 to 5.0 μg/L, and the blood
level is 5.0 μg/L for an occupationally unexposed
population.

 No level of lead is safe in human body.


Table 1: Sociodemographic and occupational variables of the study
participants (n = 97) with their saliva lead levels
Table 2: Sociodemographic and occupational factors associated with saliva
lead levels in the study participants
Table 3: Multiple linear regression analysis of association between
sociodemographic and occupational variables with saliva lead levels in the
study participants
In Our Study
 Our findings suggest that blue collar workers in
industrial zones could be occupationally exposed to
lead, especially those with significant smoking history,
longer years of occupational exposure, and
particularly in car mechanics.
Recommendations

 Further studies are still needed to investigate and


correlate lead levels in blue collar workers and other
populations.

 Health regulatory agencies should take measures to


reduce such exposures and improve health outcomes
in those at risk.
 REFERENCES

 1. Fresquez MR, Pappas RS, Watson CH. Establishment of toxic metal reference range in tobacco from US
cigarettes. J Anal Toxicol. 2013;37(5):298-304.
 2. Muennig P. The Social Costs Of Lead Poisonings. Health Aff (Millwood). 2016;35(8):1545.
 3. Karri V, Schuhmacher M, Kumar V. Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive
dysfunction: A general review of metal mixture mechanism in brain. Environ Toxicol Pharmacol. 2016;48:203-
13.
 4. Ferreira de Mattos G, Costa C, Savio F, Alonso M, Nicolson GL. Lead poisoning: acute exposure of the
heart to lead ions promotes changes in cardiac function and Cav1.2 ion channels. Biophys Rev. 2017;9(5):807-
25.
 5. Li C, Ni ZM,Ye LX, Chen JW, Wang Q, Zhou YK. Dose-response relationship between blood lead levels
and hematological parameters in children from central China. Environ Res. 2018;164:501-6.
 6. Laidlaw MA, Zahran S, Pingitore N, Clague J, Devlin G, Taylor MP. Identification of lead sources in
residential environments: Sydney Australia. Environ Pollut. 2014;184:238-46.
 7. Ozbek N, Akman S. Determination of lead, cadmium and nickel in hennas and other hair dyes sold in
Turkey. Regul Toxicol Pharmacol. 2016;79:49-53.
 8. Kasuba V, Rozgaj R, Milic M, Zeljezic D, Kopjar N, Pizent A, et al. Evaluation of genotoxic effects of lead
in pottery-glaze workers using micronucleus assay, alkaline comet assay and DNA diffusion assay. Int Arch Occup
Environ Health. 2012;85(7):807-18.
 9. de Araujo GC, Mourao NT, Pinheiro IN, Xavier AR, Gameiro VS. Lead Toxicity Risks in Gunshot Victims.
PLoS One. 2015;10(10):e0140220.
 10. Attina TM, Trasande L. Economic costs of childhood lead exposure in low- and middle-income
countries. Environ Health Perspect. 2013;121(9):1097-102.
 11. Cao S, Duan X, Zhao X, Wang B, Ma J, Fan D, et al. Levels and source apportionment of children's lead
exposure: could urinary lead be used to identify the levels and sources of children's lead pollution? Environ
Pollut. 2015;199:18-25.
 REFERENCES 2

 12. Staff JF, Harding AH, Morton J, Jones K, Guice EA, McCormick T. Investigation of saliva as an alternative matrix to
blood for the biological monitoring of inorganic lead. Toxicol Lett. 2014;231(2):270-6.
 13. Thaweboon S, Thaweboon B, VeerapradistW. Lead in saliva and its relationship to blood in the residents of Klity
Village in Thailand. Southeast Asian J Trop Med Public Health. 2005;36(6):1576-9.
 14. Nriagu J, Burt B, Linder A, Ismail A, SohnW. Lead levels in blood and saliva in a low-income population of Detroit,
Michigan. Int J Hyg Environ Health. 2006;209(2):109-21.
 15. Costa de Almeida GR, Umbelino de Freitas C, Barbosa F, Jr., Tanus-Santos JE, Gerlach RF. Lead in saliva from lead-
exposed and unexposed children. SciTotal Environ. 2009;407(5):1547-50.
 16. Brodeur J, LacasseY, Talbot D. Influence of removal from occupational lead exposure on blood and saliva lead
concentrations. Toxicol Lett. 1983;19(1-2):195-9.
 17. Youravong N, Teanpaisan R, ChongsuvivatwongV. Salivary lead in relation to caries, salivary factors and cariogenic
bacteria in children. Int Dent J. 2013;63(3):123-9.
 18. Omokhodion FO, Crockford GW. Lead in sweat and its relationship to salivary and urinary levels in normal healthy
subjects. Sci Total Environ. 1991;103(2-3):113-22.
 19. Gandhi J, Hernandez RJ, Chen A, Smith NL, SheynkinYR, Joshi G, et al. Impaired hypothalamic-pituitary-testicular
axis activity, spermatogenesis, and sperm function promote infertility in males with lead poisoning. Zygote. 2017;25(2):103-
10.
 20. Uzu G, Sauvain JJ, Baeza-Squiban A, Riediker M, Hohl MS, Val S, et al. In vitro assessment of the pulmonary toxicity
and gastric availability of lead-rich particles from a lead recycling plant. Environ SciTechnol. 2011;45(18):7888-95.
 21. Hayatbakhsh MM, Oghabian Z, Conlon E, Nakhaee S, Amirabadizadeh AR, Zahedi MJ, et al. Lead poisoning among
opium users in Iran: an emerging health hazard. Subst Abuse Treat Prev Policy. 2017;12(1):43.
 To the Faculty of Medicine in An-Najah National
University.

 To Dr. Ramzi Shawahna and Dr. Ahed Zyoud.

 To the Department of Water and Environmental


Studies Institutes (WESI).

 To our families and the kind audience .

 And a shout out to every worker agreed to


participate in the study.

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