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03 IncidencePreval
03 IncidencePreval
Department of Epidemiology
Gillings School of Global Public Health
University of North Carolina at Chapel Hill
www.unc.edu/epid600/
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 3
“This `telephone´ has too many
shortcomings to be seriously considered
as a means of communication. The device
is inherently of no value to us.”
- Western Union internal memo, 1876
(Source: 2000 National Ernst & Young Entrepreneur of the
Year Awards special insert in USA Today, 2/11/2000, p9B)
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 4
“Everything that can be invented
has been invented.”
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 5
“The wireless music box has no imaginable
commercial value. Who would pay for a
message sent to nobody in particular?”
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
9/11/2005 Incidence and prevalence 6
“My thesis in this lecture is that
macroeconomics . . . has succeeded: Its
central problem of depression-prevention
has been solved, for all practical purposes,
and has in fact been solved for many
decades.”
- Robert E. Lucas, Jr., American Economics Association
Presidential Address, January 10, 2003
http://home.uchicago.edu/~sogrodow/homepage/paddress03.pdf
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
1/25/2011 Incidence and prevalence 7
The population perspective requires
measuring disease in populations
Vase or faces?
Which line is
longer?
1/25/2011 Incidence and prevalence 9
Measurement “captures” the phenomenon
O
O
O
O
O
O
O
5/20/2002 Incidence and prevalence 11
How can we quantify disease in populations?
O
1/25/2011 Incidence and prevalence 12
How can we quantify disease in populations?
O
O
1/25/2011 Incidence and prevalence 13
How can we quantify disease in populations?
O
O
O
5/20/2002 Incidence and prevalence 14
How can we quantify disease in populations?
OO
O
O
O
5/20/2002 Incidence and prevalence 15
How can we quantify disease in populations?
OO
O O
O
O
5/20/2002 Incidence and prevalence 16
How can we quantify the frequency?
OO
O O
O
O
1/25/2011 Incidence and prevalence 17
Rate of occurrence of new cases
per unit time (e.g., 1 per month)
OO
O O
O
O
1/25/2011 Incidence and prevalence 18
1 new case in month 1
O
5/20/2002 Incidence and prevalence 19
1 new case in month 2
O
O
5/20/2002 Incidence and prevalence 20
1 new case in month 3, for a total of 3 cases
O
O
O
5/20/2002 Incidence and prevalence 21
2 new cases in month 4
OO
O
O
O
5/20/2002 Incidence and prevalence 22
1 new case in month 5 (total=6)
OO
O O
O
O
5/20/2002 Incidence and prevalence 23
1 case in month 6
OO
O O
O
O
O
5/25/2011 Incidence and prevalence 24
1 new case in month 7
OO
OO O
O
O
O
5/20/2002 Incidence and prevalence 25
2 new cases in month 8
OO
OO O
O
OOO
O
5/20/2002 Incidence and prevalence 26
2 cases in month 9
OO
OO O
O
O
O OOO
O
5/20/2002 Incidence and prevalence 27
Rate of occurrence of new cases during 9 months:
1 case/month to 2 cases/month
OO
OO O
O
O
O OOO
O
1/9/2007 Incidence and prevalence 28
Number of cases depends on length of interval
O
O
O
O
O
O
O
1/25/2011 Incidence and prevalence 38
What proportion of the population
is affected after 1 month? (1/200)
O
1/30/2004 Incidence and prevalence 39
What proportion of the population
is affected after 2 months? (2/200)
O
O
5/20/2002 Incidence and prevalence 40
What proportion of the population
is affected after 3 months? (3/200)
O
O
O
5/20/2002 Incidence and prevalence 41
What proportion of the population is
affected after 4 months? (5/200)
OO
O
O
O
5/20/2002 Incidence and prevalence 42
6 / 200 = 0.03 = 3% = 30 / 1,000
in 5 months
OO
O
O
O
O
1/9/2007 Incidence and prevalence 43
Incidence proportion (“cumulative incidence”)
Number of deaths
Annual mortality rate = ––––––––––––––––––––––
Mid-year population (x 1 yr)
Number of deaths
Annual mortality rate = ––––––––––––––––––
Mid-year population
6/6/2002 Incidence and prevalence 51
Mortality rates versus incidence rates
• Mortality data are more generally available
• Fatality reflects many factors, so mortality
rates may not be a good surrogate of incidence
rates
• Death certificate cause of death not always
accurate or useful
OO
O O
O
O
O
5/20/2002 Incidence and prevalence 54
1 new case, 1 new death
OO
OO O
O
O
O
5/20/2002 Incidence and prevalence 55
2 new cases, no deaths
OO
OO O
O
OOO
O
5/20/2002 Incidence and prevalence 56
2 new cases, 1 new death
OO
OO O
O
O
O OOO
O
5/20/2002 Incidence and prevalence 57
What is the prevalence? (9 / 197)
OO
OO O
O
O
O OOO
O
5/20/2002 Incidence and prevalence 58
Fine points . . .
•Who is “at risk”?
• Endometrial cancer? Prostate cancer?
Breast cancer?
• Only women who have not had a
hysterectomy?
“Could” develop the condition + “would” be
counted.
5/20/2002 Incidence and prevalence 59
More fine points
• Age?
• Immunity?
• Genetically susceptible?
Population
at risk
Deaths,
cures, etc.
5/20/2002 Incidence and prevalence 66
Incidence, prevalence, duration of hospitalization
Remote community of 101,000 people
One hospital, patient census = 1,000
Steady state
500 admissions per week
Prevalence = 1,000/101,000 = 9.9/1,000
IR = 500/100,000 = 5/1,000/week
Duration Prevalence / IR = 2 weeks
1/25/2011 Incidence and prevalence 67
Relation of incidence and prevalence
Juan Shizu
Km LpK Km LpK
Interstate 800 0.050 200 0.045
Other 200 0.100 800 0.080
Total 1,000 0.060 1,000 0.073
Juan Shizu
% LpK % LpK
Interstate 80 0.050 20 0.045
Other 20 0.100 80 0.080
Total 100% 0.060 100% 0.073
•Juan’s Suburu:
= 0.60 x 0.050 LpK + 0.40 x 0.100 LpK =0.070 LpK
•Shizu’s Mazda:
= 0.60 x 0.045 LpK + 0.40 x 0.080 LpK =0.059 LpK
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 77
“A cookie store is a bad idea.
Besides, the market research reports
say America likes crispy cookies,
not soft and chewy cookies like you make.”
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 78
“Computers in the future may weigh
no more than 1.5 tons.”
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 79
“I think there is a world market
for maybe five computers.”
FAMOUS LAST WORDS: quotations that demonstrate the value of humility in predicting the future
5/20/2002 Incidence and prevalence 80