• A continuous flow of blood for supply of oxygen and nutrients. • Two- third of the coronary blood flow occurs during diastole. • 5% of the cardiac output goes to the coronary arteries. • During times of extreme demand coronary arteries can dilate upto four times greater than normal CONTD… • Coronary blood flow in humans is about 225- 250 ml per minute. • During exercises increases to 3 to 6 fold. • Blood flow to the left is twice right ventricle. MEASUREMENT OF CORONARY BLOOD FLOW • Nitrous oxide method ( key method). • Radionuclides utilization technique. • Coronary angiographic technique. • Electromagnetic flow meter technique. FACTORS AFFECTING CORONARY BLOOD FLOW • Mean aortic pressure. • Muscular pressure. • Emotional excitement. • Hypotension. • Hormones. • Heart rate. • Effect of ions. • Metabolic factors. • Temperature.