Plummer Vinson syndrome with squamous cell carcinoma of

hypophaynx and esophagus : A rare case presentation

Chandana.Sanjee1,Vijay.Bhaskar1,Reshma2 ,Rahul.R 1, Yashaswini.S 1,Swaroopa.C 1.
1Radiation oncology , 2Pathology
HCG Hospital, Bangalore

INTRODUCTION INVESTIGATION
• In India the incidence of hypopharyngeal cancers is •Biopsy: From the ulceroproliferative lesion in the
1:100,000 . posterior pharyngeal wall extending to post cricoid area.
•The exact incidence of Plummer Vinson syndrome is •Histopathological Examination: Well differentiated
unknown. Squamous cell carcinoma .
•Plummer-Vinson Syndrome (PVS) was first described •USG neck : Hypoechoic mass lesion of 5cm length
by Patterson and Kelly in 1919. involving the pharyngo-esophageal junction.
•Plummer-Vinson syndrome is defined by the classic •CT scan of Head , Neck and Chest showed
triad of dysphagia, iron-deficiency anemia and circumferential irregular thickening with heterogenous
esophageal webs. enhancement noted in the hypo-pharyngeal –esophageal
juction and enlarged bilateral level 2 lymph nodes
CASE REPORT
• A 35 year old lady presented to the hospital with
complaints of progressive dysphagia and generalized
weakness since 1 year.
• Initially she could tolerate solid food but now was
able to take only semi-solid food.
DISCUSSION
• Patient physically looked emaciated, severely
dehydrated, pale and lethargic . She weighed 45kg.
• There was bilateral angular stomatitis, glossitis with
epithelial crust on the lips. The skin appeared
generally dry and the finger nails were spoon shaped.
• On upper GI endoscopy an ulceroproliferative lesion
was seen in the posterior pharyngeal wall extending
to post cricoid area.
• Tachycardia was noted on cardiovascular
examination.

CONCLUSION

References:
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