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DEFENSE
RESPONSES
CHAPTER III
UNIT 2
YOUR BODY DOES NOT EASILY GIVE WAY TO DISEASES. IT GIVES A GOOD
FIGHT BEFORE IT GIVES UP.
THE OUTERMOST COVERING OF THE BODY IS THE FIRST BARRIER AGAINST INVASION OF MICROBES. THIS INCLUDES THE SKIN, MUCOUS
MEMBRANES THAT LINE THE RESPIRATORY TUBES, UROGENITAL TRACTS, AND DIGESTIVE TUBE.
N O N S P E C I F I C I M M U N I T Y ( I N N AT E )
HERE, THE BODY USES A BATTERY OF CELLS THAT ARE PART OF THE NONSPECIFIC IMMUNE SYSTEM. THE CELLS SECRETE CHEMICALS AND
PROTEINS THAT HELP IN THE DESTRUCTION OF PATHOGENIC MICROORGANISMS.
FOR EXAMPLE;
THIS HAPPENS WHEN YOU CUT PART OF YOUR SKIN AND MICROBES ENTER THE WOUND.
THE SECOND LINE OF DEFENSE TAKE ACTION WHEN THE FIRST LINE OF DEFENSE IS BREACHED BY MICROBES.
I N T E G U M E N TATA R Y S Y S T E M
THE BODY IS ALSO PROTECTED BY THE SPECIFIC IMMUNE SYSTEM. THIS CAN IDENTIFY AND REMOVE THE PATHOGENIC MICROORGANISMS THAT
HAVE EVADED THE INNATE IMMUNE SYSTEM. ONE KIND OF IMMUNE CELL CAN AGGRESSIVELY ATTACT AND KILL ANY CELL IDENTIFIED AS
FOREIGN.
THE BODY ENCOUNTERS
DISEASES-CAUSING MICROBES
FROM TIME TO TIME.
MOST OF THESE MICROBES NATURALLY
INHABIT THE BODY AND ARE HARMLESS;
OTHERS, HOWEVER, ARE PATHOGENIC AND
CAUSE DISEASES.
THE BODY HAS BUILT-IN PROTECTIVE BARRIERS WHICH ARE PART OF THE IMMUNE
SYSTEM, THE ONES THAT COUNTER ANTIGENS TO SAFEGUARD THE BODY.THESES ARE
THE MECHANICAL AND CELLULAR DEFENSES, THE ANTIBODIES WE PRODUCE TO WARD
OFF FOREIGN SUBSTANCES. THE ABILITY TO PRODUCE THESE ANTIBODIES IS CALLED
HUMORAL IMMUNITY.
TYPES OF
IMMUNITY
1. ACQUIRED
IMMUNITY
THIS TYPE OF IMMUNITY IS A
GENETIC PREDISPOSITION. WE
RECEIVE THIS TYPE OF
IMMUNITY FROM OUR
PARENTS AND
ANCESTORS.
2. INBORN
IMMUNITY
ANTIBODIES COULD BE
OBTAINED WHEN WE ARE
EXPOSED TO ANTIGENS.THIS
HAPPENS IN EITHER
NATURAL OR
ARTIFICIAL
MANNER. ACQUIRED IMMUNITY
PROGRESS THE MOMENT A
PERSON IS BORN.
a. NATURALLY ACQUIRED
IMMUNITY
This type of acquired immunity occurs
when the person is exposed to a live
01 ACTIVE
Active immunity is obtained once a person comes in direct contact
pathogen, develops the disease, and
becomes immune as a results of primary with a disease which providers a permanent immunity. This could
immune response. This happens in be done by administering a prepared vaccine, whether weakened or
active or passive form. dead antigens, to stimulate the production of certain antibodies. In
some cases, booster shots are needed. This provides a long-term
immunity
02 PASSIVE
Passive immunity is obtained during fetal development
through the mother’s placenta and by breastfeeding upon
b. ARTIFICIAL ACQUIRED
IMMUNITY
Artificially acquired immunity can also be in an active or passive
rearing the newborn. This may last for a short period of time. form. In other words, it can be introduced through a vaccine, a
Passive immunity is acquired promptly after a person has substance that contains the antigens.
been exposed to a precarious disease, which could be
detrimental to the person’s health (e.g., diphtheria, pertussis,
rabies.
Human
The
Immune
System
antibodies
T H E S E A R E S T I M U L AT E D W I T H T H E P R E S E N C E O F
A N T I G E N S I N T H E B O D Y W H I C H A R E E V E N T U A L LY
DESTROYED.
ANTIGENS ARE
SUBSTANCES WHICH COULD BE
FOREIGN
ANTIGENS
DETRIMENTAL TO HEALTH.
AN
ANTI-
BODY
STRUCTURE
THE FIVE TYPES OF ANTIBODIES
OR IMMUNOGLOBULINS AND THEIR FUNCTIONS ARE AS FOLLOWS:
IgG
IS MAINLY PRESENT IN CIRCULATION WHICH COMES IN CONTACT
DIRECTLY WITH PATHOGENS. THIS IS THE MAJOR FORM OF
ANTIBODY FOUND IN
BLOOD PLASMA
AND PRODUCED IN A SECONDARY IMMUNE RESPONSE. IT IS THE ONLY
ANTIBODY THAT CAN CROSS THE PLACENTA FROM THE MOTHER TO
THE FETUS BECAUSE OF ITS SMALL MOLECULAR SIZE.
IgA
MOST EXISTS IN BODILY SECRETIONS SUCH AS
MUCOSAL LININGS
OF THE DIGESTIVE AND RESPIRATORY TRACTS.
THEY ATTACH TO ANTIGENS SO AS NOT TO REACH THE BLOODSTREAM.
IgM
WHICH IS THE
BROADEST,
IS ALSO FOUND CIRCULATING IN THE BODY.THEY ARE THE
FIRST TO ENCOUNTER THE PATHOGENS THAT REACH THE
BLOODSTREAM
IgE
PLAYS A BIG ROLE IN ALLERGIC REACTIONS, PARTICULARLY IN STIMULATING THE
RELEASE OF
HISTAMINES.
HISTAMINE, WHICH IS A CHEMICAL COMPOUND PRODUCED AND STORED IN
SOME BODY CELLS THAT ARE PART OF THE IMMUNE SYSTEM, IS RELEASED WHEN
THE BODY EXPERIENCES AN ALLERGIC REACTION.
IgD
SIGNIFIES ANTIGEN-ANTIBODY TYPE DIFFERENTIATION.
IMMUNE
SYSTEM
IS SUBJECT TO SEVERAL DISORDERS.
ASTHMA, FOR EXAMPLE, OCCURS DUE TO HYPERSENSITIVITY OF THE AIRWAYS TO DUST, POLLEN,
AND OTHER ALLERGENS WHICH CAN RESULT IN BRONCHOCONSTRICTION, MUCOSAL EDEMA, AND
INCREASED PRODUCTION OF RESPIRATORY SECRETION THAT ALL LEAD TO DIFFICULTY IN BREATHING.
PATIENTS WITH MODERATE TO SEVERE ASTHMA NEED TO HAVE INHALERS TO PROVIDE BRONCHODILATION
AND SOMETIMES STERIODS IN ORDER TO LESSEN INFLAMMATION AND NARROWING OF AIRWAYS.
VACCINATION
IS THE PROCESS OF INTRODUCING AN ATTENTED OR WEAKEND ANTIGEN IN A SUSCEPTIBLE
HOST.
IT IS DONE FOR THE PURPOSE OF INCREASING IMMUNITY AGAINST A PARTICULAR INFECTIOUS AGENT.
DURING THE FIRST IMMUNE RESPONSE, THE PRIMARY ANTIBODIES PRODUCED ARE THE IgM TYPE, FOLLOWED A FEW DAYS
LATER BY THE IgG TYPE.
ONCE THE ADAPTIVE IMMUNE RESPONSE IS ABLE TO ELIMINATE THE AGENT, SOME OF THE LYPHOCYTES
BECOME MEMORY CELLS.
WHEN THESE CELLS ARE STIMULATED, SUCH AS IN INSTANCES WHERE THE HOST ENCIUNTERS THE SAME
ANTIGEN (GETS SICK WITH THAT SAME MICROBE), RAPID ELEVATION OF ANTIBODIES OF IgG OCCURS.
LYMPHOCYTES
OBTAIN AN INCREASED CAPABILITY OF FIGHTING OFF ANTIGENS AT RELATIVELY LOWER DOSES
THAN DURING THE FIRST ENCOUNTER.
B-CELL
DIFFERENTIATION BEGINS EARLIER AFTER ANTIGEN STIMULATION THAN DURING THE
FIRSTRESPONSE. DURING SUBSEQUENT ENCOUNTERS, IMMUNE ACTIVITY BECOMES MORE
INTENSE AND VIGOROUS ACCOUNTING FOR THE RAPID ELEVATION OF IgG LEVELS WHICH
PROTECTS AAGAINST THE INFECTION.
VACCINATION
LESSON SUMMARY
SOME FUNGI MAY ENTER THE PLANT THROUGH THE STOMATA OF LEAVES.
FUNGAL HYPHEA CAN PENETRATE THE CELL WALLS BUT NOT THE CELL
MEMBRANES. THE CLOSE CONTACT BETWEEN THE FUNGAL HYPHAE AND THE
CELL MEMBRANE, FACILITATES EASY TRANSFER OF PLANT NUTRIENTS TO THE
FUNGI, THUS HARMING THE PLANTS.
HOWEVER, THERE ARE SOME BACTERIA AND FUNGI THAT ARE BENEFICIAL TO PLANTS
Rhizobium
Which lives around the roots of plants, benefit from root saps or exudates.
In turn, these bacteria provide substances such as hormones needed for
plants growth.
Azospirillium
PROTEINASE
through the plant body to initiate production of
Chemical defenses
Plants have a unique way of protecting themselves. Some plants are famous for their toxins which kill their enemies. Some
of these toxins are cyanides.
The cyanide-containing compounds are called cyanogenic glycosides that break down into cyanide when
ingested.
CYANIDE
can stop cellular respiration by blocking the electron transport chain.
When this happens , it kills the attacking organism. Filipinos are very fond of cassava.
They cook it in different ways. The preparation of cassava as food is very crucial. There is a need
to scrub-off and thoroughly wash the outer covering of the modified roots before they are
cooked.
This part is filled with cyanogenic glycosides that break down into MANIHOTOXIN, a bitter
and toxic material. Some plants produce other toxins that make herbivores ill.
Others repel them with their strong odors and flavors.
The Hemlock Plants, CONIUM MACULATUM, is a highly poisonous plant that could
kill a person from 20 minutes to three hours after ingestion of its extract. The philosopher
Socrates died by drinking hemlock extract, a nuerotoxin, which paralyzes the body.
Ricin, an alkaloid found in castor beans RICINUS COMMINIS, is six times more lethal than
cyanide and is twice as lethal as the venom of cobra.
Plants can also contain other secondary metabolites that may
affect herbivores including human.
Alkaloids found in plants such as caffeine, cocaine, nicotine, and morphine can
affect cellular processes.
Plants can over stimulate the consumer which could be lethal to them.
Plant oils in high concentrations can also be toxic upon ingestion.
The secondary metabolites are enclosed in membrane-bound organelles
which are separated from the rest of the c y t o p l a s m so that they do not get
involved in cellular metabolism.
Another is that the toxins they produce are not harmful unless metabolized by the consumer.
Some have to be ingested first and then metabolized by the body to become toxic.
Plants can also poison other plants. Some plants produce
chemical toxins
that are released to the ground which may prevent
seed germinations
or inhibit the growth of other competing plants.
This strategy, which is called allelopathy , minimizes shading
and overcrowding among plants.
The poison can either affect plants of the same species or of a different species.
For example, where you find black walnuts, you will also notice spacing between trees.
LESSON SUMMARY
Plants have two general types of defenses mechanisms: physical and chemical
defenses.
Physical defense structures in plants include trichomes, barks, spines, and thorns.
Chemical defenses involve the production of toxins.
Plants may also produce toxins such as manihotoxin in cassava.
Castor beans produce a very potent toxin called ricin.
Secondary metabolites in plants help drive away predators.
Secondary metabolites include caffeine, cocaine, nicotine, and morphine.
Allelopathy among trees help drive away neighboring trees and results in spacing.
CHAPTER TEST
CHAPTER TEST
7. The type of immunity that is most rapidly developed in the body of a patient is
a) Passive immunity
b) Active immunity
c) Toxoid immunity
d) Natural immunity
9. Antibodies are
a) B-cells
b) Lipids
c) Y-shaped proteins
d) T-cells
CHAPTER TEST
12. Which of the following is a bitter and toxic chemical found in cassava?
a) Ricin
b) Nicotine
c) Morphine
d) Manihotoxin
CHAPTER TEST
13. Which of the following does not explain why plants are not poisoned by the toxins
they produced?
a) Plants produce an antidote against the toxins
b) The toxins they secrete may be covered in membrane-bound organelles
c) The toxins are separated from the rest of the cytoplasm
d) Plants produce toxins that must be ingested and metabolized first
14. Which of the following illustrates how plants can benefit from microorganisms?
a) Plants leaves turn yellow because of microorganisms
b) Fungal hyphae penetrate cell walls and absorb nutrients from the plant
c) Microorganisms cause tumorous outgrowth in plants
d) Microorganisms invade root hairs and stimulate the production of gibberellic acid
1. C
2. D
3. A
4. A
5. C
6. A
7. -
8. A
9. A
10. C
11. D
12. B
13. A
14. D
15. d