DEVELOPMENT OF COATED TABLETS USING

POLYMER BLEND TECHNIQUE

Duangratana Shuwisitkul, Sujimon Tunvichien, Chalisa Thamdamrong, Thanachat Sumirattana
Faculty of Pharmacy, Srinakharinwirot University

Background Results and discussion

Objectives
To develop coated tablets as a controlled release system which
provided zero order release and investigate factors affecting the Fig.1 : Temperature sweep of polymer blended
drug release of coated tablet. (HPMC:Zein 50:50)
Materials and methods
Materials
Zein protein (Acros organics, China) ,Hydroxypropyl methylcellulose
(The dow chemical company, USA), Propranolol hydrochloride
(Changzhou Yabang Pharmaceutical Co.,LTD, China), Theophylline
anhydrous (Jilin Shulan Synthetic Pharmaceutical Co.,LTD, China),
Polyethylene
Methods glycol 400 (PEG 400) (Optimal chemicals, Malaysia)
Preparation of
polymer solution

Rheological Preparation of
properties free films

Results and discussion

Film/polym Tg (DSC) Tg
er (Rheology)
HPMC powder 161.36
HPMC film 172.41 77.00
HPMC + TEC 114.37 38.91
HPMC + PEG 98.21 76.50
HPMC + PEG + 143.77 63.78
SLS
HPMC : Zein 50 : 148.85 77.12
50
HPMC : Zein 60 : 165.48 77.54
40
HPMC : Zein 70 : 151.84 77.50
30
HPMC : Zein 80 : 150.77 77.24
20