PR LAPSUS

AKNE VULGARIS
Nadya Ratu Aziza Fuady
Retinoid - Kolagen

kolagenase

GAG
High glycemic
• Indeks glimekik (IG)

Peningkatan
Proliferasi Contribute
produksi
sebosit to acne
sebum

Aktivitas androgen dan

insulin-like growth factor-
1 (IGF-1)

Indeks glikemi
Dairy products
• The hormones in milk, such as IGF-1, 5α-reductace may
survive milk processing and affect the pilosebaceous unit.
Fats
• Omega-3: ikan dan sayuran
• Omega-6: kacang-kacangan, biji-bijian, dan produk
daging

Asam lemak Mensupresi

omega-3 lebih sitokin
tinggi pro-inflamasi

Penurunan
produksi IGF-1
Alcohol

Stimulasi
DHEAS
kelenjar adrenal
Chemical peeling
Superficial medium Deep

Pigmentary
Dyschromia Photoaging
Disorder

Acne Superficial scars Deep scars

Post Inflammatory
Wrinkles
Hyperpigmentation

Melasma
Salisilic acid Glycolic acid
5-30% 20-70%

Mencegah obstruksi Exfoliasi dengan cara epidermolisis

Menyebabkan penebalan pada lapisan

Menetralisir bakteri
epidermis dan dermis
Trichloroacetic acid Solusio jenner’s

14% LA, 14% SA, 14% resorcinol

15-50%
dalam 95% etanol

Denaturasi protein penyusun Tujuan: menghancurkan hubungan

epidermis dan dermis antar keratinosit

Menyebabkan penebalan pada lapisan

reoorganization
epidermis dan dermis
THANK YOU!
Calcinosis cutis
dystrophic, metastatic, idiopathic,
iatrogenic, and calciphylaxis

• Dystrophic: systemic • Iatrogenic

sclerosis, dermatomyositis, • Calciphylaxis: calcification
mixed connective tissue
of small and medium-
disease, lupus
sized vessels and is
• Metastasic:  abnormal
associated with chronic
serum levels of calcium and
renal failure and dialysis
phosphorus
• Idiopathic: tumoral
calcinosis, subepidermal
calcified nodules, and
scrotal calcinosis
Dystrophic calsification
- phosphate-binding
proteins
Tissue damage - chronic
inflammation
- vascular hypoxia

Tumor necrosis factor

(TNF), IL-6, IL-1B,
binds phosphate and
contribute to the
results in calcification
formation of the
calcium salt
Calcinosis cutis
Treatment
• Diltiazem -- High doses at 2 mg/kg/d to 4 mg/kg/d
• Warfarin -- 1 mg/d
• Bisphosphonates -- Etidronate is used at 800 mg/d
• Minocycline -- 50 mg to 100 mg/d 
• Ceftriaxone -- 2g/d for 20 days 
• Alumunium hydroxide -- 2.24 g/d, 2.4 g/d, and 1.8 g/d for
calcinosis cutis in dermatomyositis and lupus
• Probenecid -- 1.5 g/d 
• Topical sodium thiofosfate
• Others