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ANESTHETICS
Tetracaine Pr”i”locaine
Cocaine Mep”i”vacaine,
Et”i”docaine
PHARMACOLOGY OF LOCAL
ANESTHETICS
PHARMACOLOGY OF LOCAL
ANESTHETICS
Properties:
esters amides
Lidocaine 10-20 min 4.5 mg/kg (7 mg/kg) 120 min (240 min)
• Topical anesthesia
• Local infilteration
• Peripheral nerve blocks
• Tumescent technique
TOPICAL/SURFACE ANESTHESIA
• Uses :
▫ Oral surgeries, nasal intubation, superficial surgical
procedure
• Advantages :
▫ technically easy
▫ minimal equipment
• Disadvantages :
▫ potential for large doses leading to toxicity
COCAINE SUBSTITUTIONS
• Uses:
▫ Suturing, minor superficial surgery, line placement, more
extensive surgery with sedation
• Advantages:
▫ minimal equipment, technically easy, rapid onset
• Disadvantages:
▫ potential for toxicity if large field
PERIPHERAL NERVE BLOCK
• Uses
▫ any surgical procedure on an extremity
• Advantages:
▫ technically simple, minimal equipment, rapid onset
• Disadvantages:
▫ duration limited by tolerance of tourniquet pain,
toxicity
Minor nerve block
•Injecting local anesthetic near the
course of a named nerve
•Uses:
• Surgical procedures in the
distribution of the blocked nerve
•Advantages:
• relatively small dose of local
anesthetic to cover large area;
rapid onset
•Disadvantages:
• technical complexity,
neuropathy
PLEXUS BLOCKAGE
• Injection of local anesthetic adjacent to a plexus,
e.g cervical, brachial or lumbar plexus
• Uses :
▫ surgical anesthesia or post-operative analgesia in
the
distribution of the plexus
• Advantages:
▫ large area of anesthesia with relatively large dose of
agent
• Disadvantages:
▫ technically complex, potential for toxicity
and neuropathy.
TUMESCENT TECHNIQUE
• Large volumes of local anesthetic lidocaine (0.05%-1%) with
diluted EPI (1:500,000 to 1:1,000,000) for both anesthetic
and hemostatic effects.
• Safe technique,less toxicity levels, tissue plane for dissection
• For example, a mixture of 1000 mL of normal saline with 25 mL
of 2% lidocaine,I g/ml adrenaline will result in a concentration
of lidocaine upto .05%,adrenaline in 1:1000,000.
• maximum dose of lidocaine with epinephrine=7 mg/kg
during routine use. However, when used for tumescence
during liposuction, this ceiling is dramatically increased to
35 mg/kg (others report up to 55 mg/kg)
Recipe for Tumescent Technique Anesthetic Solutions
for Body Liposuction