Kelainan Imunitas

 Hypersensitivity Reactions
 Autoimmune Disease
 Immunodeficiency
 Hypersensitivity Reactions(HS)
Type I Immediate HS (Anaphylaxis)
mekanisme :
Ag Ig E (Ig G 4) Mast cell
Degranulasi mediators
(Release Vasoactive Substances)
contoh :
Drug Allergies, Hay Fever
 Type II Antibody Mediated Cytotoxicity
mekanisme :
Ab Ag cell surface
cell Damage

contoh : Hemolytic disease – New Born

Goodpasteur’s Syndrome
 Type III Immune Complex Disorders
mekanisme :
Ag – Ab complex Deposit
Aktivas Complement
contoh :
serum sickness, Arthus dll.

 Type IV cell – mediated HS

mekanisme :
Ag – T cells Lymphokines
Aktivasi M0
contoh :
Contact Dermatitis dll.
 Autoimmune Disease

 Systemic
Systemic Lupus Erythematosus (SLE)
Rheumatoid Arthritis, Ankylosina Spondylitis
Sjögren’s syndrome
polyarteritis Nodosa dll.
• Organ specific
Liver Chronic Liver Disease
Kidney Goodpasteur’s syndrome
Acute Poststreptococcal Nephritis
Muscle Myasthenia Gravis
Heart Rheumatic Fever
Eye Uveitis, Sympathetic Ophtalmia
Skin Dermatitis Herpetiformis
LE, Bullous Pemphigoid
Pemphigus Vulgaris
Blood Anemia, Leukopenia,
Thrombocytopenia
Cns Allergic Encephalitis, Demyelinating
Disease
Endocrine Thyroiditis,
Hypoparathyroidism Juvenile,
Addison’s Disease
Gastro Intestinal pernicious Anemia,
Ulcerative, Colitis dll.
• Immunodeficiency
• Virus
• Genetic Disorder
• Malnutrisi

• Genetic
• B Cells
• T Cells
• Complement
• Combined
• Dll.