- Plasters are solid or semisolid masses adhere to

the skin when spread upon cotton felt line or

muslin as a backing material and they are mainly
used to,
A- Afford protection and mechanical support.
B- Furnish an occlusive and macerating action.
C- Bring medication into close contact with the
surface of the skin.
•Protective
liner
•Drug
containing
layer
•Backing
layer
 adhesive plasters
 medicated plasters are used for local or
regional drug delivery
 transdermal delivery (or therapeutic) systems
(TTS) are used for long-term systemic
delivery of therapeutic agents through the
skin.
 Examples: Nitroderm TTS, Estraderm TTS,
Durogesic, etc.
 Also called a sticking plaster
 Is a small dressing used for injuries not
serious enough to require a full-
size bandage.
 The adhesive bandage protects the cut from
friction, bacteria, damage, or dirt.
 Thus, the healing process of the body is less
disturbed.
 Sometimes they have antiseptic properties.
 An additional function is to hold the two cut
ends of the skin together to make the healing
process faster.
 An adhesive bandage is usually covered by
woven fabric, plastic, or latex rubber which
has an adhesive.
 Adhesive bandages usually have an absorbent
pad, which is sometimes medicated with an
antiseptic solution.
 Some bandages have a thin, porous-polymer
coating over the pad to keep it from
sticking to the wound.
 The bandage is applied such that the pad
covers the wound, and the fabric or plastic
sticks to the surrounding skin to hold the
dressing in place and prevent dirt from
entering the wound.
 Band-Aid
 Curad
 Elastoplast
 Nexcare
 Versatis medicated plasters
Versatis medicated plasters contain the
active ingredient lidocaine.

Main use Active ingredient Manufacturer

Nerve pain following

Lidocaine Grunenthal
shingles
 Use with caution in
 Severely decreased liver function.
 Severely decreased kidney function.
 Severe heart problems.
 People taking medicines to treat an irregular
heart beat, for example mexiletine.
 People using other local anaesthetics.
Contents:
 TTS 5 Patches: The average amount of active

substance nitroglycerine releases per

application in 24 hrs is 5mg (Per hour
releases 0.2mg).

TTS 10 Patches: The average amount of
active substance nitroglycerine releases per
application in 24 hours is 10mg (Per hour
releases 0.4mg).
 Drug Classification: Glyceryl Trinitrate Patch
 Trade Name Manufacturer(s):
Novartis
 Estraderm TTS patches contain the active
ingredient estradiol ,which is a naturally
occuring form of the main female sex
hormone, oestrogen.

Main use Active ingredient Manufacturer

Symptoms of the Estradiol Novartis
menopause
Used for
 Hormone replacement therapy to relieve

symptoms of the menopause.

 Second-line option for

preventing osteoporosis in postmenopausal

women who are at high risk of fractures
and cannot take other medicines licensed
for preventing osteoporosis (Estraderm TTS
50 only).
Use with caution in
 Decreased kidney function.

 Heart failure.

 History of diabetes.

 History of gallstones.

 History of migraines or severe headaches.

 History of epilepsy.

 History of asthma.
Side effects
 Breakthrough bleeding and spotting.

 Breast pain, tenderness or enlargement.

 Headache/migraine.

 Redness or itching at patch application site.

 Leg cramps.

 Fatigue.

 Weight changes.

 Vaginal thrush.

 Depression.

 Anxiety.

 Dizziness.
 Duragesic (fentanyl) is an opioid analgesic
that is used for patients with chronic pain
that is persistent, not managed by other
opioids or non-steroidal analgesics, and are
opioid-tolerant.
USES
DURAGESIC is a transdermal formulation of
fentanyl indicated for the management of
persistent, moderate to severe chronic
pain in opioid-tolerant patients 2 years
of age and older when a continuous.
SIDE-EFFECTS
 Nausea, vomiting,

 dry mouth, constipation,

 hypotension and hypertension,

 bradycardia, somnolence,

 confusion, hallucinations,

 euphoria, pruritus, sweating and

 urinary retention.
 www.netdoctor.co.uk
 www.pakmedinet.com
 Remington: The Science and Practice of
Pharmacy 21st edition pages no
948,1029,2309.