PRAVASTATIN

STATIN

Reagan JW. Pravastatin: A First Generation HMG CoA Reductase Inhibitor ☆ [Internet]. 2nd ed. Reference Module in
Biomedical Sciences. Elsevier Inc.; 2018. 1–10 p. Available from: http://dx.doi.org/10.1016/B978-0-12-801238-
3.97874-7
 Safety Concerns

•   Feb 28, 2012, the FDA changes label safety

On
1) Potential cognitive effects
2) Hyperglycemia
3) Myopathy / rhabdomyolysis

Routine monitoring of liver enzymes no longer

warranted

Reagan JW. Pravastatin: A First Generation HMG CoA Reductase Inhibitor ☆ [Internet]. 2nd ed. Reference Module in
Biomedical Sciences. Elsevier Inc.; 2018. 1–10 p. Available from: http://dx.doi.org/10.1016/B978-0-12-801238-3.97874-7
 Pravastatin in pregnancy?

Risk Benefit
 Birth Defect
Not associated with a significant increase in
birth defects
Miscarriage risk

Significant increase in miscarriage

risk

Elective Termination of Pregnancy

More than twice of control subjects to
undergo elective terminations of pregnancy

Zarek J, Koren G. Motherisk rounds: The Fetal Safety of Statins: A Systematic Review Meta-Analysis. J Obstet Gynaecol
Canada [Internet]. 2014;36(6):506–9. Available from: http://dx.doi.org/10.1016/S1701-2163(15)30565-X
FDA APPROVAL
CONTRAINDICATIONS
IN SPECIFIC POPULATIONS
EXPERIMENT STUDY
STATIN EXPOSURE DURING PREGNANCY
STATIN EXPOSURE DURING PREGNANCY
OTHER BENEFIT
 A F U T UR E
ME A S
BECO M S IA
P RE- EC L A
P Y ? ? ?
THERA
 NEW POTENTIAL REPRODUCTIVE

1. ENDOMETRIOSIS
2. POLYCYSTIC OVARY SYNDROME
3. RECURRENT PREGNANCY LOSS (IN AN ANIMAL
MODEL)
4. UNINTENTIONALLY CONCEIVE
 CONCLUSION
• Much studies suggest there is a need for RE-
EVALUATION of this categorization
THANK YOU