Welcome

Objectives
• Explain pathologic calcification
• Define inflammation
• Causes of inflammation
• Types of inflammation
• Signs of inflammation
• Mediators of inflammation & their effects
• Outcomes of acute inflammation
• Consequences of defective and excessive inflammation
 Pathologic calcification
• The abnormal deposition of mostly calcium salts, with smaller amounts of iron,
magnesium and other mineral salts in tissues.
• The calcification of tissues other than bone and teeth.
 Pathologic calcification
 Two forms of pathologic calcification

• 1. Dystrophic calcification: deposition occurs in dying tissues e.g necrosis, aging or

damaged
• E.g. on the heart valves. This occurs as a reaction to tissue damage, can occur even if
the amount of calcium is not elevated in the blood.

• 2. Metastatic calcification: deposition of calcium salts in normal tissues mostly as a result

of Hypercalcemia (increased levels of calcium in the blood) e.g Hyperparathyroidism and
renal failure.