USES

 Chronic pain, migraine headaches, muscle spaticity,

spinal corf injury, movement disorder, appetite
stimulation in patient with AIDS, nausea and
vomiting
 Tolerance with continued heavy use and withdrawal
syndrom (depression, anxiety, sleep disturbence,
tremor etc)
 Cannabinoids are teratogenic in animals but effect n
humans is unproved, although there is impaired fetal
growth in repeated use
 MORPHINE & HEROIN

 Opioid analgesic for treatment severe pain (cancer-

related pain)
 Addiction : behaviour problem
 MODE OF ACTION

 Bind to and blocks the dopamine reuptake

transporter, dopamine accumulates and acts on
adjacent neurones to produce the characteristic
“high”
 Psychotropic effecs = amphetamine (euphoria and
excitement)
 Phsychotropic and physical dependence and
tachyphylaxis
 Overdoses (>22%), euphoria and excitement turns
to acute fear with phychotic symptoms, convulsons
 AMFETAMINS

 Multivarious uses, for depression and as appetite suppresant

and sport abuse
 Cristal meth or ice use as phychostimulant
 Amfetamine acts centrally by releasing dopamine stored in
nerve ending and pheripheral by alfa and beta-adrenoceptor
 acting as sympathomimetics (CNS)  pshycological
effects vary with mood, personality and environment as well
as with dose
 Severe dependence induce behaviour disorders,
hallucinations and psychosis
 Acuate : excitement and convulsion
 Chronic overdose : schizophrenia
 AMFETAMINS

 Dexamfetamine :
 Methylphenidate
 Tenampfetamin (ecstacy)
 Phentermine
 Diethylpropion
 Premoline
Terima kasih