BIOINFORMATICS – AS A

TOOL TO FIGHT
ANTIBIOTIC RESISTANCE

MARTYNA GŁUSIEC
ABSTRACT
INTRODUCTION

• ANTIBIOTIC - REFERRING AS ANY ORGANIC SUBSTANCE

HAS BACTERICIDAL OR BACTERIOSTATIC ACTIVITY
THAT TRIGGERS DIFFERENT TARGET SITES OF
BACTERIAL CELL. OVERUSE AND MISUSE OF THESE
MEDICAMENTS CONTRIBUTED TO THE DEVELOPMENT
OF THE ANTIBIOTIC RESISTANCE IN MANY BACTERIA
STRAINS.

• ANTIBIOTIC RESISTANCE -
• ANTIMICROBIAL PEPTIDES (AMPS) –

•  
•  
• THESE APPROACHES HAVE THE ADVANTAGE OF PROVIDING A RAPID SURVEY OF THE ANTIBIOTIC RESISTOME OF NEW STRAINS, THE DISCOVERY OF NEWLY EMERGENT
ANTIBIOTIC RESISTANCE GENES, THE EPIDEMIOLOGY OF ANTIBIOTIC RESISTANCE GENES, AND THE HORIZONTAL GENE TRANSFER (HGT) OF KNOWN ANTIBIOTIC
RESISTANCE GENES THROUGH PLASMIDS AND TRANSPOSABLE ELEMENTS. HOWEVER, DESPITE THE EXISTENCE OF TOOLS FOR GENERAL ANNOTATION OF
PROKARYOTIC GENOMES (SEE, E.G., REFERENCE 8), PREDICTION OF AN ANTIBIOTIC RESISTANCE PHENOTYPE FROM A GENOME SEQUENCE IS NOT STRAIGHTFORWARD
AND, TO DATE, COMPUTATIONAL TOOLS FOR COMPREHENSIVE PREDICTION OF ANTIBIOTIC RESISTANCE GENES WITHIN GENOMES HAVE BEEN LACKING.
•  
• THE INCREASING OPPORTUNITY TO PREPARE A BROADER AND COMPREHENSIVE ANTIBIOTIC RESISTANCE GENE CENSUS IS FACILITATED BY THE POWER AND FALLING
COSTS OF NEXT-GENERATION DNA SEQUENCING. FOR EXAMPLE, WHOLE-GENOME SEQUENCING (WGS) IS BEING INCREASINGLY USED TO EXAMINE NEW ANTIBIOTIC-
RESISTANT ISOLATES DISCOVERED IN CLINICAL SETTINGS
•  
• ONE OF THE EXAMPLES OF FOCUSING BIOINFORMATICS RESEARCH ON AMR IS RECOGNITION OF ANTIMICROBIAL PEPTIDES. ANTIMICROBIAL PEPTIDES ARE…
METHODS

• AUTODOCK
A LIGAND IS AN ORGANIC MOLECULE THAT MAKE COMPLEX
WITH BIOMOLECULES AND HAVE THE TENDENCY TO PRODUCE
CONFORMATIONAL CHANGES (CHANGE IN SHAPE ).
RESULTS
DISCUSSION
REFERENCES
• [1] S. BIN ZAMAN, M. A. HUSSAIN, R. NYE, V. MEHTA, K. T. MAMUN, AND N. HOSSAIN, “A REVIEW ON ANTIBIOTIC
RESISTANCE: ALARM BELLS ARE RINGING,” CUREUS, VOL. 9, NO. 6, PP. E1403–E1403, JUN. 2017, DOI:
10.7759/CUREUS.1403.
• [2] M. LAWS, A. SHAABAN, AND K. M. RAHMAN, “ANTIBIOTIC RESISTANCE BREAKERS: CURRENT APPROACHES AND
FUTURE DIRECTIONS,” FEMS MICROBIOL. REV., VOL. 43, NO. 5, PP. 490–516, MAY 2019, DOI: 10.1093/FEMSRE/FUZ014.
• [3] HEMLATA AND A. TIWARI, “APPLICATIONS OF BIOINFORMATICS TOOLS TO COMBAT THE ANTIBIOTIC
RESISTANCE,” INT. CONF. SOFT COMPUT. TECH. IMPLEMENTATIONS, ICSCTI 2015, PP. 96–98, 2016, DOI:
10.1109/ICSCTI.2015.7489545.
• [4] D. VELTRI, U. KAMATH, AND A. SHEHU, “DEEP LEARNING IMPROVES ANTIMICROBIAL PEPTIDE RECOGNITION,”
BIOINFORMATICS, VOL. 34, NO. 16, PP. 2740–2747, 2018, DOI: 10.1093/BIOINFORMATICS/BTY179.
• [5] J. M. FREIRE, S. A. DIAS, L. FLORES, A. S. VEIGA, AND M. A. R. B. CASTANHO, “MINING VIRAL PROTEINS FOR
ANTIMICROBIAL AND CELL-PENETRATING DRUG DELIVERY PEPTIDES,” BIOINFORMATICS, VOL. 31, NO. 14, PP. 2252–
2256, 2015, DOI: 10.1093/BIOINFORMATICS/BTV131.
• [6] A. G. MCARTHUR ET AL., “THE COMPREHENSIVE ANTIBIOTIC RESISTANCE DATABASE,” ANTIMICROB. AGENTS
CHEMOTHER., VOL. 57, NO. 7, PP. 3348–3357, 2013, DOI: 10.1128/AAC.00419-13.
• [7] A. G. MCARTHUR AND G. D. WRIGHT, “BIOINFORMATICS OF ANTIMICROBIAL RESISTANCE IN THE AGE OF
MOLECULAR EPIDEMIOLOGY,” CURR. OPIN. MICROBIOL., VOL. 27, PP. 45–50, 2015, DOI: 10.1016/J.MIB.2015.07.004.
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