Rapid-onset Poisoning

- Symptoms manifest within 30 minutes

Cause:

1. Inocybe & Clitocybe species

2. Amanita Muscaria
Delayed-Onset Mushroom Poisoning
Manifestation
a. Rapid-onset type
- Manifestation - 30 minutes to 2 hours after ingestion.
- Upset stomach
- disulfiram-like reaction
- hallucination
- nausea
- Vomiting
- diarrhea
- urgency
- sweating
- salivation
- bronchoconstriction
MANIFESTATIONS:

B. Delayed Onset Type

● Manifestations initially appear 6-
12 hours after ingestion
● Potentially life-threatening
Three basic types of delayed-onset mushroom poisonings:

1. Gastrointestinal/ headache/ liver

damage
● Noted toxin:
Monomethylhydrazine (MMH)
● Bloated feeling, nausea, vomiting,
diarrhea, abdominal pain,
headache, muscle cramps, and
vertigo.
2. Gastrointestinal/liver damage
● Noted toxin: Amatoxins
● Three Stage Progression:
1. 12-24 hours after ingestion
■Vomiting, diarrhea, severe abdominal pain
(persists for 24 hours)
2. Symptoms remit and patient seems to
recover. Premature hospital release has
resulted in death.
3. Symptoms resume with increased severity
and are accompanied by symptoms of liver
failure & failure of other organs. Death may
occur in 4 to 7 days.
3. Kidney, later liver damage
● Noted toxin: Orellanine
● Delayed onset of 36 hours to 14
days.
○ Kidney failure symptoms are
noted first
○ Extreme thirst, Frequent urination,
pain in the lumbar region, chills or
fever, diarrhea, or constipation.
TREATMENT
Rapid Onset Type - IV ATROPINE 1-2 mg

Delayed Onset Type - SUPPORTIVE TREATMENT