FEBRILE SEIZURE

FEBRILE SEIZURE
• Seizures that occur between ages 6 and 60 months with a
temperature of ≥38 ⁰C
• Not a result of CNS infection or any metabolic imbalance
• Occur in the absence of prior afebrile seizures
Types
• Simple Febrile Seizure
• Complex Febrile Seizure
• Febrile Status Epilepticus
• Simple Febrile Seizure Plus
GENETIC FACTORS
• Positive family history of febrile seizures
• Autosomal dominant
• Affects multiple single genes
• FEB 1-10 on chromosomes 8q13-q21, 19p13.3, 2q24, 5q14-q15,
6q22-24, 18p11.2, 21q22, 5q34, 3p24.2-p23 and 3q26.2-q26.33

• Epilepsies that are preceded by febrile seizure

• Generalized epilepsy w/ febrile seizures plus (GEFS+)
• Severe myoclonic epilepsy of infancy (Dravet syndrome)
Generalized epilepsy w/ febrile seizures plus
(GEFS+)
• Autosomal dominant syndrome
• Onset is usually in early childhood and remission is
usually mid-childhood
• Characterized by multiple febrile seizures and by several
subsequent afebrile generalized seizures including
generalized tonic-clonic, absence, myoclonic, atonic or
myoclonic astatic seizures with variable degrees of
severity
Dravet syndrome
• Most severe
• Febrile and afebrile unilateral clonic seizures recurring
every 1 or 2 months
• Prolonged, more frequent febrile convulsions
• Seizures start with low fevers then without fever
• 2nd year of life – myoclonus, atypical absences and partial
seizures occur frequently and developmental delay
usually follows
• Usually caused by de novo mutation of gene located on
2q24-31 and encodes for SCN1A – loss of function