Quality Study of Cyclobenzaprine in Multi

Relax
3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-
dimethylpropan-1-amine hydrochloride Production area of film coated tablet
Uses • Productions areas should be well lit, particularly where visual on-line controls are carried out.

• Premises should preferably be laid out in such a way as to allow the production to take place in areas connected
• Cyclobenzaprine is used short-term to treat muscle spasms.
in a logical order corresponding to the sequence of the operations and to the requisite cleanliness levels.
• It is usually used along with rest and physical therapy.
• It works by helping to relax the muscles. • Production area contain Coating Section.

Sampling Coating section

• Five multirelax tablets were weighed accurately and powdered. An amount of equivalent to 100 mg of cb • Coating section contain Coating Equipment such as(Standard Coating Pan, Perforated Pan, Fluidized Bed/Air
was weighed into 100 ml volumetric flask and extracted with 50ml methanol using an ultrasonic bath for 30 Suspension System).
minutes, diluted to volume with the same solvent and filtered. Into 50 ml of the filtered solution suitable
dilutions were made using methanol to prepare tablet solution containing 1 mg/ml for methods 2.5 ml of the
Standard Coating Pan
solution was accurately transferred to a 10ml volumetric flask and was diluted to volume with methanol to
 Metal pan between about 15 and 200 cm in diameter that is tilted on a benchtop stand. The pan can be rotated
prepare tablet solution containing 0.25 mg/ml.
with an electric motor.

Analysis  A batch of tablets are loaded into the pan which is set to rotate. The rotating motion causes the tablets to tumble
within the pan. Coating solution is applied to the rotating tablet bed by spraying in atomized form which can
1.HPLC produce a faster and more even distribution than simply introducing it as a liquid.

Samples were dissolved in 0.05 N sulfuric acid and diluted with methanol. The cyclobenzaprine  Drying efficiency can easily be achieved by use of a baffled pan and diffuser which allows the distribution of
hydrochloride was chromatographed using an octylsilane column and the eluent acetonitrile 0.6% dibasic drying air uniformly over the surface of the tablets.
potassium phosphate aqueous buffer (pH 3.0) (75:25) at a flow rate of 1.5 ml/min. Naphazoline hydrochloride
was used as an internal standard. The UV detector response at 254 nm was linear for cyclobenzaprine
hydrochloride in the 0.005–0.03 mg/ml range under conditions of the analysis
Chromatogram of Cyclobenzaprine hydrochloride tablet solution containing added Naphazoline
Standard Coating Pan
hydrochloride as internal standard.
(I) cyclobenzaprine
(II) naphazoline.

Ahmed abdallah Prof.Dr/ Hesham

eltayeb Abir mahmoud
Aya Ragab KhalifaFatma mohamed Salem
Fatma elzahraa ali Prof.Dr/ Kamal Badr