Acid Base Balance

Concentration of H+ & pH
Concentration of H+ & pH
 Buffering of H+

Buffer systems
Hemoglobine (HHb/KHb)
Bicarbonate (H2CO3/NaHCO3)
Phosphates (NaH2PO4/ Na2HPO4)
Proteins
Hemoglobine buffer

Н+ + КНЬ = К+ + ННЬ.
Bicarbonate buffer system
Hendenrson-Hasselbach equation
Titration curve for bicarbonate
buffer system
 Phosphate buffer system
• HCL+ Na2HPO4  NaH2PO4 +NaCL
• NaOH +NaH2PO4  Na2HPO4+H2O
Role of respiration
Reabsorption of bicarbonates
Secretion of H+
Secretion of H+
Phosphate urinary buffer
Ammonia/ammonium urinary buffer
NH3/NH4+
Regulation of H+secretion
BLOOD TYPES
 Rh blood types
• Antigens CDE cde

• 85% are Rh positive blood- with

antigen D
• 15% - Rh negative with antigen d
 Erythroblastosis Fetalis

• Rh negative mother &Rh positive father

• 1st pregnancy- minimal risk
• Prevention: Rh immunoglobulin globin –
anti D antibody