Application

and example of
IDDS
Implant Drug Delivery System

Eltanin Gamal
1806199303
HG-04
INTRODUCTION
Implantable drug delivery devices have
the potential to be used for a wide
variety of clinical applications in areas
including:

 Women’s health
 Chronic disease
 Infection diseases
(Tuberculosis)
 Neurology and central
nervous system health
WOMEN’S
HEALTH
 Norplant = contraception
 Silicone intravaginal ring (IVR) = to treat
symptoms associated with menopause and
releases 2 mg estradiol for 90 days
Estring

Product name Implant Type Material Drug Indication

Delivered
Norplant Sub-cutaneous Silicone Levonorgestrel Contraception
Jadelle
Estring Intra-vaginal Silicone Estradiol Menopausal
symptoms
Nuvaring Intra-vaginal PEVA Etonogestrel, Contraception
Ethinyl
estradiol
Implanon Sub-cutaneous PEVA Etonogestrel Contraception
Nexplanon
 CHRONIC
DISEASE
a. Cardiovascular disease
Drug-eluting stents (DES) = for vascular
disease treatment. DES consist of Bare metal
stents (BMS) coated with a polymer which
gradually releases a drug to inhibit cell
proliferation that causes coronary artery from
narrowing again (restenosis) after angioplasty.
This installed DES will remain in the coronary
arteries and over time it will unite with the
coronary arteries.
 CHRONIC
DISEASE
b. Cancer
To deliver chemotherapeutic drugs safely and effectively Zoladex
without side effects

Product name Implant Type Material Drug Delivered Indication

Zoladex Sub-cutaneous PLGA Goserelin Prostate cancer
Prostap SR Sub-cutaneous PLGA Leuprolide Prostate cancer
Gliadel Wafers Intra-tumoral Intra-tumoral Carmustine Primary
(BCNU) malignantglioma
Oncogel Intra-tumoral PLG-PEG-PLGA Paclitaxel Oesophageal
cancer
Vantas Sub-cutaneous Methacrylate Histrelin Prostate cancer
based hydrogel
GemRIS Intra-vesical ND Gemcitabine Non-muscle
invasive Bladder
Cancer
 CHRONIC
DISEASE
c. Diabetes
Implantable System have the potential to transform the current standard of both diagnosis and treatment

 On the diagnostic end, continuous glucose monitoring

(CGM) may be achieved by SC implanted sensors for blood
glucose measurement

 DUROS implant delivery technology is to help treat type II

diabetes. It has the cylindrical reservoir osmotic pump,
enclosed by a titanium alloy package. When implanted SC,
it delivers over 1 year exenatide, a glucagon-likepeptide-1
receptor agonist
continuous glucose monitoring
 CHRONIC
DISEASE

d. Ocular therapy Ocusert

Implantable System have the potential to transform the current
standard of both diagnosis and treatment
Product name Implant Type Material Drug Delivered Indication
Ocusert Intra-ocular PEVA Pilocarpine, Open angle
Alginic acid glaucoma
Retisert Intra-ocular Microcrystalline Fluocinolone Non-infectious
cellulose, PVA, uveitis
Magnesium
stearate
Vitrasert Intra-ocular PVA, PEVA Ganciclovir CMV retinitis in
AIDS patients
 CHRONIC
DISEASE
e. Pain Management
Chronic pain need repeated dosage, morbidity and mortality from overdosing and the high risk for addiction to
oral and parenteral medications

Product name Implant Type Material Drug Delivered Indication

ND (Axxia Sub-cutaneous PU,PEG/PPG/PT Hydromorphine Chronic
Pharmaceutical) MEG neuropathic pain

 Axxia Pharmaceuticals has a patented design for a subcutaneous, drug-eluting device with
zero-order kinetics for continuous 30-90 day delivery of hydromor-phine. The device is aimed
at treating patients suffering from cancer or HIV/AIDS-induced neuropathic chronic pain.
 INFECTION
DISEASES
(TUBERCULOSIS)
 The treatment of tuberculosis (TB) is the long duration of therapy and side effects of
drugs, which can hamper patient lifestyle and induce patient noncompliance, treatment
failure, and development of drug resistant strains
 IDDSs are a promising approach for the development of more effective and more
compliant DDSs for TB treatment

Product name Implant Type Material Drug Indication

Delivered
ND ND PLGA Isoniazid TB
ND ND PLGA Isoniazid, TB
Pyrazinamide
 NEUROLOGY AND CENTRAL NERVOUS
SYSTEM HEALTH

Product Implant Material Drug Indication

name Type Delivered
Med- Sub- PLGA Risperidone Schizophren
Launch cutaneous ia
ND Sub- PU Risperidone Schizophren
cutaneous ia
Risperdal Intra- PLGA Risperidone Schizophren
consta muscular ia

Rispendal consta