KATABOLISME

ASAM LEMAK
Triacylglycerols
fuel the long
migration flight
of the American
Golden Plover
(Pluvialis
dominica)
Degradasi lemak

Adipocyte. A small band of

cytoplasm surrounds a large
deposit of triacylglycerols
 Fatty acids degradation and fatty
acids synthesis are mirror process
Fatty acids
degradation
and synthesis
are relatively
simple
processes that
are essentially
the reverse of
each other
 Fatty acids degradation

The process of degradation

converts an aliphatic compounds
into a set of activated acetyl units
(acetyl CoA) that can be process
by the citric acid cycle (TCA)
 Fatty acids degradation
• an activated fatty acids is oxidized to
introduce a double bond
• the double bond is hydrated to
introduce an oxygen
• the alcohol is oxidized to a ketone
• finally, the four carbon is fragment is
cleaved by a coenzyme A to yield acetyl
CoA and a fatty acid chain with two
carbons shorter
1
2
3
4
Aktivasi asam lemak
Gliserol
Glycerol
• Triacylglycerol in the intestinal lumen
are incorporated into micelles formed
with the aid of bile salts, amphipathic
molecules synthesized from
cholesterol in the liver and secreted
from the gall bladder
• Incorporation of lipids into micelles
allow lipid digestion by pancreatic
lipases that are in aqueous solution
Bile salt, such as glycocholate, facilitate lipid digestion in the intestine
Actions of pancreatic lipases
 Intestinal epithelial

Lipids are transported in the form of chylomicrons

Palmitoil-CoA + 7 FAD + 7 NAD+ + 7 CoA + 7 H2O →
8 Asetil-CoA + 7 FADH2 + 7 NADH + 7 H+
∑ATP sitosol = 10,5 (7 FADH2 ) + 17,5 (7 NADH ) +
80 (8 Asetil-CoA ) – 2 (ATP → AMP + 2 Pi)
= 106