HUBUNGAN

DEPRESI DAN HIV

(Pada HPA Axis)

KHALIDA KHAIRUNNISA
G1A217099
HIV & DEPRESSION : DIRECT & INDIRECT

Schuster R, Bornovalova M,
Hunt E. The influence of
depression on the
progression of HIV: Direct
and indirect effects. Behav
Modif. 2012;36(2):123–45.
STRESS  HPA AXIS

Chrousos GP, Zapanti ED.

Hypothalamic-Pituitary-
Adrenal Axis in HIV
Infection and Disease.
Endocrinol Metab Clin North
Am. 2014;43(3):791–806.
Available from:
http://dx.doi.org/10.1016/j.ec
l.2014.06.002
HIV & HPA
AXIS

Chrousos GP, Zapanti ED.

Hypothalamic-Pituitary-
Adrenal Axis in HIV
Infection and Disease.
Endocrinol Metab Clin North
Am. 2014;43(3):791–806.
Available from:
http://dx.doi.org/10.1016/j.ec
l.2014.06.002
CORTISOL &
SHIFT OF TH-1
TH-2

Reiche EMV, Nunes SOV,

Morimoto HK. Stress,
depression, the immune
system, and cancer. Lancet
Oncol. 2004;5(10):617–25.
CONCLUSION
­
­ Stressor
GP 120 envelope (Depresi)
Infeksi virus protein
HIV Rangsang
Hipotalamus
Sitokin Inflamasi : IL-
2, IFN-Gamma, IFN-
Virus melekat di Alfa, IL-6, IL-1 & TNF- CRF
CD4+ Alfa
Rangsang Hipofisis

ACTH
Deplesi CD4+

Rangsang Korteks Adrenal

Sekresi Glukokortikoid
(kortisol) ↑

Sistem imunitas
perubahan keseimbangan Th
(pergeseran th1th2)