dr.

Fatwa Sitta
dr. M Irfan Lubis
dr. Aprilia Jati
dr. Harun Andreas Hasahatan
dr. Annisa Yuanita Anggreini
dr. Sahat Ericson Tampubolon
dr. Ria Widya Marosa
dr. Dewi Fuji Lestari
Resolution: standard / high
Figure 2.
Hypothetical pathways involved in the pathogenesis of SLE.
Nguyen et al. Arthritis Res 2002 4(Suppl 3):S255-S263   doi:10.1186/ar583
• The LE cell is a neutrophil
that has engulfed the
antibody-coated nucleus of
another neutrophil
• LE cells may appear in
rosettes where there are
several neutrophils vying for
an individual complement
covered protein.
• Fc region switch
• ζ  εγ
• Leads to malfunction in signaling
and decreased IL-2 production
• Increased levels of Ca2+
• Leads to spontaneous apoptosis
 IgG is the most “pathogenic” because it forms
intermediate sized complexes that can get to the
small places and block them.
• ELISA Test
• Generally test
for:
• ds-DNA
antibodies
• Antihistone
antibodies
• Binds to DNA,
major
constituent of
chromatin
• Deoxyribonucleo
protein (DNP)
 Used to
determine
immunological
specificity
 Rules out a
false positive
 Shows the
serum does or
does not have
antinuclear
antibodies
• Lupus = Autoimmunity
• Systemic and affects connective
tissue
• Caused by malfunctions of:
• T-cells
• B-cells
• Complement System
• Signal Transduction
• Can be lethal or not
• Unique to each individual