SCHIZOPHRENIA

PANCARONA
schiz·o·phre·ni·a
/ˌskitsəˈfrēnēə,ˌ/
Syndrome of unknown etiology
charaterized by disturbances in
cognition, emotion, preception,
thinking, and behavior.
Localization of symptom domains
 SIGN & SYMPTOM

Simtom Negatif

SCHIZOPRH
ENIA Simtom Positif
 POSITIVE SYMPTOM

Positive symptoms generally reflect an

excess of normal function. They are:

Dramatic
often the cause of bringing a patient
To the attention of medical professionals
and law enforcement
The major target of antipsychotic drug
treatments
 NEGATIVE SYMPTOM

Negative symptoms reflect the loss of normal

functions and feelings, such as losing interest
in things and not being able to experience
pleasure

Negative symptoms are:

Considered as a reductions in normal
function
Associated with long periods of
hospitalization and poor social functioning
 DOPAMINE PATHWAY

Mesocortical
Pathway

Nigrostriatal
Pathway

Mesolimbic
Pathway

Tuberoinfudibular
Pathway
MESOLIMBIC PATHWAY

• Area tegmental  nucleus accumbens

• Mengatur gejala positif
• Jalur yang hiperaktif bertanggung
jawab terhadap delusi dan halusinasi
MESOCORTICAL PATHWAY

Mesocortical Pathway to Dorsofrontal

Cortex
• Ventral tegmental  prefrontal cortex
• Terlibat dalam gejala negatif dan
kognitif  hipoaktif jalur ini

Mesocortical Pathway to Venteromedial

Prefrontal Cortex
• Proyeksi mesocortical dopamin 
VMPC
• Gejala negatif  hipoaktif jalur ini
NIGROSTRIATAL PATHWAY

• Substansia nigra  basal ganglia atau

striatum
• Bagian saraf ekstrapiramidal dan
mengontrol fungsi motorik dan
gerakan
• DA berlebih  pergerakan hiperkinetik
seperti tik dan diskinesia
• Menurunnya dopamin 
parkinsonism
• SR tanpa treatmen  aktivasi jalur ini
diduga “normal”
TUBEROINFUNDIBULAR
PATHWAY

• Hipotalamus  kelenjar pituitari

• Sebagai sekresi prolaktin
THANKS!

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